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Sonoko Narisawa
Researcher at Discovery Institute
Publications - 101
Citations - 8072
Sonoko Narisawa is an academic researcher from Discovery Institute. The author has contributed to research in topics: Alkaline phosphatase & Hypophosphatasia. The author has an hindex of 45, co-authored 97 publications receiving 7283 citations. Previous affiliations of Sonoko Narisawa include National Foundation for Cancer Research & Washington University in St. Louis.
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Journal ArticleDOI
Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization
Lovisa Hessle,Kristen Johnson,H. Clarke Anderson,Sonoko Narisawa,Adnan Sali,James W. Goding,Robert Terkeltaub,José Luis Millán +7 more
TL;DR: The results suggest that inhibiting PC-1 function may be a viable therapeutic strategy for hypophosphatasia, and interfere with TNAP activity may correct pathological hyperossification because of PPi insufficiency.
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Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.
Dympna Harmey,Lovisa Hessle,Sonoko Narisawa,Kristen Johnson,Robert Terkeltaub,José Luis Millán +5 more
TL;DR: In this article, the authors crossbred Akp2−/− mice to ank/ank mice and found a partial normalization of the mineralization phenotypes and PPi levels.
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Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia
TL;DR: In the mouse, TNAP appears not to be essential for the initial events leading to bone mineral deposition but that TNAP seems to play a role in the maintenance of this process after birth, indicating the nonessential role of EAP during embryonic development.
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Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia
Kenton N. Fedde,Libby Blair,Julie Silverstein,Stephen P. Coburn,Lawrence M. Ryan,Robert S. Weinstein,Katrina G. Waymire,Sonoko Narisawa,José Luis Millán,José Luis Millán,Grant R. MacGregor,Michael P. Whyte,Michael P. Whyte +12 more
TL;DR: It is demonstrated that TNSALP knock‐out mice are a good model for the infantile form of hypophosphatasia and compelling evidence for an important role for TNSalP in postnatal development and mineralization of the murine skeleton is provided.
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Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition
Ross F. Goldberg,William G. Austen,Xiao Bo Zhang,Gitonga Munene,Golam Mostafa,Shaluk Biswas,Michael C. McCormack,Kyle R. Eberlin,John Nguyen,Hamit S. Tatlidede,H. Shaw Warren,Sonoko Narisawa,José Luis Millán,Richard A. Hodin +13 more
TL;DR: It is demonstrated that the brush–border enzyme, intestinal alkaline phosphatase (IAP), has the ability to detoxify lipopolysaccharide and prevent bacterial invasion across the gut mucosal barrier under conditions of starvation and disease.