S
Socrates J. Tzartos
Researcher at Pasteur Institute
Publications - 264
Citations - 10381
Socrates J. Tzartos is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Acetylcholine receptor & Myasthenia gravis. The author has an hindex of 47, co-authored 254 publications receiving 9552 citations. Previous affiliations of Socrates J. Tzartos include Laboratory of Molecular Biology & Salk Institute for Biological Studies.
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Mapping of surface structures of electrophorus acetylcholine receptor using monoclonal antibodies.
TL;DR: Forty monoclonal antibodies to acetylcholine receptor from the electric organs of Electrophorus electricus have been characterized by immunoglobulin isotype, affinity for receptor, and specificity for species, subunit, and determinants within subunits.
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Monoclonal antibodies used to probe acetylcholine receptor structure: localization of the main immunogenic region and detection of similarities between subunits.
TL;DR: In this article, 17 cell lines producing monoclonal antibodies against Torpedo californica (torpedo) acetylcholine receptor (AcChoR) and its subunits were established.
Monoclonal antibodies used to probe acetylcholine receptor structure: Localization of the main immunogenic region and detection of similarities between subunits (interspecies crossreaction/muscle/experimental autoimmune myasthenia gravis)
TL;DR: The unexpected similarities between alpha and beta and between gamma and delta subunits raise the possibility that the complex four-subunit structure of AcChoR was derived from a simpler precursor and suggests that these antigenic similarities might reflect some structural and functional homologies.
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Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies
TL;DR: The data suggest that the autoimmune response in MG is stimulated by human receptor rather than a crossreacting (e.g., viral) antigen and that in both MG and experimental autoimmune MG the pattern of specificities produced is determined by the inherently immunogenic structural features of the receptor molecule.
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Muscle and neuronal nicotinic acetylcholine receptors
Dimitra Kalamida,Konstantinos Poulas,Konstantinos Poulas,Vassiliki Avramopoulou,Efrosini Fostieri,George Lagoumintzis,Konstantinos Lazaridis,Anastasia Sideri,Marios Zouridakis,Marios Zouridakis,Socrates J. Tzartos,Socrates J. Tzartos +11 more
TL;DR: Nicotinic acetylcholine receptors (nAChRs) as mentioned in this paper are integral membrane proteins and prototypic members of the ligand-gated ion-channel superfamily, which has precursors in the prokaryotic world.