S
Sofia Braga
Researcher at BOTAŞ
Publications - 7
Citations - 869
Sofia Braga is an academic researcher from BOTAŞ. The author has contributed to research in topics: Breast cancer & Metastatic breast cancer. The author has an hindex of 3, co-authored 7 publications receiving 500 citations. Previous affiliations of Sofia Braga include Instituto Português de Oncologia Francisco Gentil & Instituto Gulbenkian de Ciência.
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Journal ArticleDOI
Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer.
Rashmi Krishna Murthy,Sherene Loi,Alicia Okines,Elisavet Paplomata,Erika Hamilton,Sara A. Hurvitz,Nan Lin,Virginia F. Borges,Vandana G. Abramson,Carey K. Anders,Philippe L. Bedard,Mafalda Oliveira,Erik Jakobsen,Thomas Bachelot,Shlomit S. Shachar,Volkmar Müller,Sofia Braga,François Duhoux,Richard Greil,David Cameron,Lisa A. Carey,Giuseppe Curigliano,Karen A. Gelmon,Gabriel N. Hortobagyi,Ian E. Krop,Sibylle Loibl,Mark D. Pegram,Dennis J. Slamon,M Corinna Palanca-Wessels,Luke Walker,Wentao Feng,Eric P. Winer +31 more
TL;DR: In heavily pretreated patients with HER2-positive metastatic breast cancer, including those with brain metastases, adding tucatinib to trastuzumab and capecitabine resulted in better progression-free survival and overall survival outcomes than adding placebo.
Journal ArticleDOI
The aggressiveness of cancer care in the last three months of life: a retrospective single centre analysis.
Sofia Braga,Ana Miranda,Rute Fonseca,José Luís Passos-Coelho,Aires Fernandes,José Duro da Costa,António Moreira +6 more
TL;DR: Evaluated the use of chemotherapy in the last three months of life in a cohort of adult patients with advanced solid tumours with concerns that terminally ill patients are over treated with chemotherapy, even when such treatment is unlikely to palliate symptoms.
Journal ArticleDOI
Complete response in HER2+ leptomeningeal carcinomatosis from breast cancer with intrathecal trastuzumab.
TL;DR: It is believed that intrathecal trastuzumab administration should be prospectively evaluated to confirm clinical activity and optimize dose, schedule, and duration of treatment.
Journal ArticleDOI
Sexual dysfunction in breast cancer survivors: cross-cultural adaptation of the Sexual Activity Questionnaire for use in Portugal
Filipa Alves da Costa,Manuel Ribeiro,Sofia Braga,Elisabete Carvalho,Fátima Francisco,Ana Miranda,António Moreira,Lesley Fallowfield +7 more
TL;DR: The adapted Sexual Activity Questionnaire is a valid tool for assessing sexual function in breast cancer survivors in Portugal and future research should focus on the validation of this scale in samples with different characteristics and even in the overall population to enable generalizability of the findings.
Journal ArticleDOI
Does Hypoxic Response Mediate Primary Resistance to Sunitinib in Untreated Locally Advanced Breast Cancer
Sofia Braga,Joana Cardoso,Saudade André,Margarida Brito,Pedro Sanchez,Lurdes Orvalho,Lucilia Salgado,Sergio Dias,José B. Pereira-Leal,José Luís Passos-Coelho +9 more
TL;DR: Evidence of primary resistance to sunitinib is found, likely mediated by up-regulation of hypoxia responsive genes, in tumors resistant to single-agent sunit inib, as evidenced by four non-responders.