Soma Mandal

TL;DR: To achieve the full benefit of developing a successful drug, multidisciplinary approaches (approaches such as computational chemistry and gene expression analysis, as discussed in this article) would be necessary.

TL;DR: A 3D structure of apoptin is calculated and through modeling and docking approaches, its interaction with Bcr-Abl oncoprotein and its downstream signaling components is shown, following which some of the newly-found interactions are confirmed by biochemical methods.

TL;DR: It is demonstrated that estradiol regulates the p21Waf1/Cip1 gene and chromatin immunoprecipitation studies provide evidence that ERα is recruited to the half‐site ERE/AP‐1 sites in the p 21Waf 1/ Cip1 upstream promoter element.

TL;DR: In a murine model of BVZ- or SNT-mediated cardiomyopathy, noninvasive assessment by TVI detected early LV systolic dysfunction before alterations in conventional echocardiographic indexes.

TL;DR: This study shows that the mechanism of IEG induction, initially elucidated in parental 10T1/2 murine fibroblast cells, applies to metastatic Hras1-transformed Ciras-3 cells, and knocksdown MSK1 knockdown Cira's3 cells lost their malignant phenotype.