C
Christopher W. White
Researcher at University of Alberta
Publications - 59
Citations - 1690
Christopher W. White is an academic researcher from University of Alberta. The author has contributed to research in topics: Transplantation & Heart transplantation. The author has an hindex of 17, co-authored 58 publications receiving 1258 citations. Previous affiliations of Christopher W. White include St. Boniface General Hospital & University of Alberta Hospital.
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Journal ArticleDOI
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
Evangelos D. Michelakis,Vikram Gurtu,Linda Webster,Gareth Barnes,Geoffrey Watson,Luke Howard,John Cupitt,Ian Paterson,Richard B. Thompson,Kelvin Chow,Declan P. O'Regan,Lan Zhao,John Wharton,David G. Kiely,Adam Kinnaird,Aristeidis E. Boukouris,Christopher W. White,Jayan Nagendran,Darren H. Freed,Stephen J. Wort,J. Simon R. Gibbs,Martin R. Wilkins +21 more
TL;DR: This first-in-human trial of a mitochondria-targeting drug in iPAH demonstrates that PDK is a druggable target and offers hemodynamic improvement in genetically susceptible patients, paving the way for novel precision medicine approaches in this disease.
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Functional assessment and transplantation of the donor heart after circulatory death.
Simon Messer,Richard G. Axell,S. Colah,Paul A. White,Marian Ryan,Aravinda Page,Barbora Parizkova,Kamen Valchanov,Christopher W. White,Darren H. Freed,Euan A. Ashley,John Dunning,Martin Goddard,Jayan Parameshwar,Christopher J.E. Watson,Thomas Krieg,Ayyaz Ali,Steven Tsui,Stephen R. Large +18 more
TL;DR: NRP allows rapid reperfusion and functional assessment of the DCD donor heart, ensuring only viable hearts are selected for transplantation and minimizes the risk of primary graft dysfunction and maximizes confidence in DCD heart transplantation, realizing a 45% increase in heart transplant activity.
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Short-term mechanical circulatory support for recovery from acute right ventricular failure: clinical outcomes.
TL;DR: Most patients with ARVF rapidly recover sufficient RV function to facilitate device explantation, highlighting an expanding role for minimally invasive temporary RV assist devices optimized for the treatment of recoverable ARVf.
Journal ArticleDOI
Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada
Darren H. Freed,Dietrich Henzler,Christopher W. White,Robert A. Fowler,Ryan Zarychanski,Jamie Hutchison,Rakesh C. Arora,Rizwan A. Manji,Jean-Francois Légaré,Tanya Drews,Stasa Veroukis,Murray Kesselman,Anne-Marie Guerguerian,Anand Kumar +13 more
TL;DR: Characteristics, treatment, and outcomes of critically ill patients in Canada who had H1N1-2009 infection and were treated with extracorporeal lung support (ECLS) are described and survival of these patients treated with ECLS is similar to that reported for patients who have acute respiratory distress syndrome of other etiologies and are treated with ECMO.
Journal ArticleDOI
Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: A survey of 100 cardiac surgeons
Subodh Verma,Bobby Yanagawa,Sameer Kalra,Marc Ruel,Mark D. Peterson,Michael H. Yamashita,Andrew Fagan,Maria E. Currie,Christopher W. White,Stephane Leung Wai Sang,Cristian Rosu,Steve K. Singh,Holly E.M. Mewhort,Nandini Gupta,Paul W.M. Fedak,Paul W.M. Fedak +15 more
TL;DR: This large survey uncovered significant gaps in the knowledge and attitudes of surgeons toward the diagnosis and management of bicuspid aortopathy, many of which were at odds with current guideline recommendations.