D
Darren H. Freed
Researcher at University of Alberta
Publications - 221
Citations - 5097
Darren H. Freed is an academic researcher from University of Alberta. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 35, co-authored 192 publications receiving 4077 citations. Previous affiliations of Darren H. Freed include Mackenzie Investments & St. Boniface General Hospital.
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Journal ArticleDOI
Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts
Jon-Jon Santiago,Aran L. Dangerfield,Sunil G. Rattan,Krista L. Bathe,Ryan H. Cunnington,Joshua E. Raizman,Kristen M. Bedosky,Darren H. Freed,Elissavet Kardami,Ian M.C. Dixon +9 more
TL;DR: C cultured neonatal and adult cardiac fibroblasts transition to myofibroblast in vitro and share expression profiles of cardiac my ofibroblast in vivo, and reduced motility with in vitro passage reflects enhanced production of focal adhesions.
Journal ArticleDOI
Survival after pulmonary thromboendarterectomy: effect of residual pulmonary hypertension.
Darren H. Freed,Bruce Thomson,Marius Berman,Steven Tsui,John Dunning,Karen Sheares,Joanna Pepke-Zaba,David P. Jenkins +7 more
TL;DR: Residual pulmonary hypertension significantly compromised symptom status and functional capacity but did not appear to adversely affect medium-term survival, and the effect of targeted medical therapy in patients with residual pulmonary hypertension after pulmonary endarterectomy needs to be evaluated further.
Journal ArticleDOI
K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts
Lisa Chilton,Susumu Ohya,Darren H. Freed,E. George,Vanja Drobic,Yoshiyuki Shibukawa,K. A. MacCannell,Yuji Imaizumi,Robert B. Clark,Ian M.C. Dixon,Wayne R. Giles +10 more
TL;DR: Results show that ventricular fibroblast and myofibroblasts express a variety of K(+) channel alpha-subunits and demonstrate that Kir current can modulate RMP and alter essential physiological functions.
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Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
Evangelos D. Michelakis,Vikram Gurtu,Linda Webster,Gareth Barnes,Geoffrey Watson,Luke Howard,John Cupitt,Ian Paterson,Richard B. Thompson,Kelvin Chow,Declan P. O'Regan,Lan Zhao,John Wharton,David G. Kiely,Adam Kinnaird,Aristeidis E. Boukouris,Christopher W. White,Jayan Nagendran,Darren H. Freed,Stephen J. Wort,J. Simon R. Gibbs,Martin R. Wilkins +21 more
TL;DR: This first-in-human trial of a mitochondria-targeting drug in iPAH demonstrates that PDK is a druggable target and offers hemodynamic improvement in genetically susceptible patients, paving the way for novel precision medicine approaches in this disease.
Journal ArticleDOI
Functional assessment and transplantation of the donor heart after circulatory death.
Simon Messer,Richard G. Axell,S. Colah,Paul A. White,Marian Ryan,Aravinda Page,Barbora Parizkova,Kamen Valchanov,Christopher W. White,Darren H. Freed,Euan A. Ashley,John Dunning,Martin Goddard,Jayan Parameshwar,Christopher J.E. Watson,Thomas Krieg,Ayyaz Ali,Steven Tsui,Stephen R. Large +18 more
TL;DR: NRP allows rapid reperfusion and functional assessment of the DCD donor heart, ensuring only viable hearts are selected for transplantation and minimizes the risk of primary graft dysfunction and maximizes confidence in DCD heart transplantation, realizing a 45% increase in heart transplant activity.