S
Song-Jun Xu
Researcher at University of Pennsylvania
Publications - 12
Citations - 220
Song-Jun Xu is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Regulation of gene expression & Epigenetics. The author has an hindex of 6, co-authored 11 publications receiving 132 citations. Previous affiliations of Song-Jun Xu include Drexel University.
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Journal ArticleDOI
Epigenetic Control of Learning and Memory in Drosophila by Tip60 HAT Action
TL;DR: It is found that both learning and immediate-recall memory deficits that occur under AD-associated, amyloid precursor protein (APP)-induced neurodegenerative conditions can be effectively rescued by increasing Tip60 HAT levels specifically in the MB.
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Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia.
TL;DR: This work is the first to confirm that N-methyl-D-aspartate receptor hypofunction is a feature of early postnatal development, with epigenetic hyper-repression of the Grin2b promoter being a contributing factor.
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Restoring Tip60 HAT/HDAC2 balance in the neurodegenerative brain relieves epigenetic transcriptional repression and reinstates cognition
Priyalakshmi Panikker,Song-Jun Xu,Haolin Zhang,Jessica Sarthi,Mariah Beaver,Avni Sheth,Sunya Akhter,Felice Elefant +7 more
TL;DR: It is demonstrated that disruption of Tip60 HAT/HDAC2 homeostasis occurs early in the AD Drosophila brain and triggers epigenetic repression of neuroplasticity genes well before Aβ plaques form in male and female larvae.
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Chromatin-mediated alternative splicing regulates cocaine-reward behavior
Song-Jun Xu,Sonia I. Lombroso,Delaney K. Fischer,Marco D. Carpenter,Dylan M. Marchione,Peter J. Hamilton,Carissa J. Lim,Rachel L. Neve,Benjamin A. Garcia,Mathieu E. Wimmer,R. Christopher Pierce,Elizabeth A. Heller +11 more
TL;DR: In this paper, the role of the epigenome in activity-dependent alternative splicing was investigated and the histone modification H3K36me3 was found to be a putative splicing regulator.
Journal ArticleDOI
Stress Regulation of Sustained Attention and the Cholinergic Attention System.
Samantha R. Eck,Song-Jun Xu,Alexander M. Telenson,Michael R. Duggan,Robert D. Cole,Brittany Wicks,Joy Bergmann,Hanna Lefebo,Marni Shore,Katherine A. Shepard,Michael R. Akins,Vinay Parikh,Elizabeth A. Heller,Debra A. Bangasser +13 more
TL;DR: These studies suggest that VS impairs attention by inducing molecular and morphological changes in the NBM, which may guide the development of novel treatments for psychiatric disorders with attention deficits.