Song Zhang

TL;DR: These animal models allow us to carefully dissect cellular and molecular mechanisms to improve understanding and facilitate development of therapeutic interventions in placental insufficiency and IUGR.

TL;DR: Experimental and clinical studies that have investigated the specific impact of exposure to maternal obesity during the periconceptional period alone or extending beyond conception on adipogenesis, lipogenesis and on insulin signalling pathways in the fat, liver and muscle of the offspring highlight the need for a better evidence base for the development of dietary interventions in obese women.

TL;DR: Findings highlight the sensitivity of the epigenome to maternal nutrition around conception and the need for dietary interventions that maximize metabolic benefits and minimize metabolic costs for the next generation.

TL;DR: Weight loss in both normal and overweight mothers during the periconceptional period results in epigenetic modification of IGF2 in the adrenal gland, adrenal overgrowth, and increased vulnerability to stress in offspring.

TL;DR: In contrast to the response to acute hypoxemia, data show that there is a redistribution of blood flow to the adrenals and temporal lobe, but not the heart or whole brain, in chronically hypoxemic PR fetuses in late gestation.