Songfeng Chen

TL;DR: Melatonin alleviated the oxidative stress‐induced apoptosis of NPCs and could be a promising alternative in treatment of IVDD.

TL;DR: RIPK1/RIPK3/MLKL-mediated necroptosis may play an important role in NP cells death induced by continuous mechanical stress, and treatment strategies which aim to regulate necroPTosis may prove beneficial, by both reducingNP cells death and slowing IVD degeneration.

TL;DR: RIPK1-mediated mitochondrial dysfunction and oxidative stress play a crucial role in NP cells necroptosis and apoptosis during compression injury and may exert more beneficial effects on NP cells survival, and ultimately delaying or even retarding intervertebral disc degeneration.

TL;DR: Ex vivo AC repair based on endogenous MSC recruitment and migration is a feasible strategy, and a promising research field, and would provide new opportunities to efficient preventative or therapeutic options for AC diseases.

TL;DR: This meta-analysis found that highly expressed 8-OHdG in tumor tissues may be a predictor of prognosis in most solid tumors, however, especially in breast cancer, low 8- OHdG expression is associated with poor prognosis, which is partly because of the increased antioxidant mechanisms in breast cancers tissues.