S
Sonja Hartwig
Researcher at University of Düsseldorf
Publications - 81
Citations - 2850
Sonja Hartwig is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 23, co-authored 70 publications receiving 2366 citations.
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Journal ArticleDOI
Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome
Daniela Lamers,Susanne Famulla,Nina Wronkowitz,Sonja Hartwig,Stefan Lehr,D. Margriet Ouwens,Kristin Eckardt,Jean Kaufman,Mikael Rydén,Stefan Müller,Franz-Georg Hanisch,Johannes Ruige,Peter Arner,Henrike Sell,Juergen Eckel +14 more
TL;DR: DPP4 is a novel adipokine that may impair insulin sensitivity in an autocrine and paracrine fashion and release strongly correlates with adipocyte size, potentially representing an important source of DPP4 in obesity.
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Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders.
TL;DR: Although the entirety of human adipokines is still incompletely characterized, to date more than 600 potentially secretory proteins were identified providing a rich source to identify putative novel biomarkers associated with metabolic diseases.
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Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes
Stefan Lehr,Sonja Hartwig,Daniela Lamers,Susanne Famulla,Stefan Müller,Franz-Georg Hanisch,Claude Cuvelier,Johannes Ruige,Kristin Eckardt,D. Margriet Ouwens,Henrike Sell,Juergen Eckel +11 more
TL;DR: Validation experiments conducted for complement factor H, αB-crystallin, cartilage intermediate-layer protein, and heme oxygenase-1 show that the release and expression of these factors in adipocytes is regulated by differentiation and stimuli, which affect insulin sensitivity, as well as by obesity.
Journal ArticleDOI
Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells.
Susanne Famulla,Daniela Lamers,Sonja Hartwig,Waltraud Passlack,A Horrighs,A Cramer,Stefan Lehr,Henrike Sell,Jürgen Eckel +8 more
TL;DR: PEDF is one of the most abundant adipokines and its secretion is inversely regulated by insulin and hypoxia, which could have an important role in diabetes and obesity-related disorders.
Journal ArticleDOI
Liver-Specific Expression of Transcriptionally Active SREBP-1c Is Associated with Fatty Liver and Increased Visceral Fat Mass
Birgit Knebel,J Haas,Sonja Hartwig,Sylvia Jacob,Cornelia Köllmer,U. Nitzgen,Dirk Muller–Wieland,Jorg Kotzka +7 more
TL;DR: The alb-SREBP-1c mouse model allowed the elucidation of the systemic impact of SREBP -1c as a central regulator of lipid metabolism in vivo and also demonstrated that the liver is a more active player in metabolic diseases such as visceral obesity and insulin resistance.