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Sonja Hombach
Researcher at University of Regensburg
Publications - 5
Citations - 736
Sonja Hombach is an academic researcher from University of Regensburg. The author has contributed to research in topics: Long non-coding RNA & Gene silencing. The author has an hindex of 5, co-authored 5 publications receiving 466 citations.
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Book ChapterDOI
Non-coding RNAs: Classification, Biology and Functioning
Sonja Hombach,Markus Kretz +1 more
TL;DR: This chapter introduces several classes of short and long non-coding RNAs, describe their diverse roles in mammalian gene regulation and give examples for known modes of action.
Journal ArticleDOI
Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer.
Nithyananda Thorenoor,Petra Faltejskova-Vychytilova,Sonja Hombach,Jitka Mlčochová,Markus Kretz,Marek Svoboda,Ondrej Slaby +6 more
TL;DR: The data suggest that ZFAS1 may function as oncogene in CRC by two main actions: via destabilization of p53 and through interaction with CDK1/cyclin B1 complex leading to cell cycle progression and inhibition of apoptosis, however, molecular mechanisms behind these interactions have to be further clarified.
Journal ArticleDOI
The non‐coding skin: Exploring the roles of long non‐coding RNAs in epidermal homeostasis and disease
Sonja Hombach,Markus Kretz +1 more
TL;DR: How lncRNAs regulate differentiation to preserve an undifferentiated epidermal progenitor compartment, and to maintain a functional skin permeability barrier is described.
Journal ArticleDOI
The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis
Christian E. Ziegler,Johannes Graf,Stefan Faderl,Jessica Schedlbauer,Nicholas Strieder,Bianca Förstl,Rainer Spang,Astrid Bruckmann,Rainer Merkl,Sonja Hombach,Markus Kretz +10 more
TL;DR: It is reported that the lncRNA LINC00941 is a crucial regulator of human epidermal homeostasis and represses SPRR5, a previously uncharacterized molecule, which functions as an essential positive regulator of keratinocyte differentiation.
Journal ArticleDOI
The oligodendroglial precursor cell line Oli-neu represents a cell culture system to examine functional expression of the mouse gap junction gene connexin29 (Cx29)
TL;DR: It is concluded that the oligodendroglial precursor cell line Oli-neu might constitute an appropriate cell culture system to study molecular mechanisms or putative extracellular stimuli to functionally open Cx29 channels or hemi-channels.