Soo-Jin Jeong

TL;DR: It is demonstrated that melatonin enhances cisplatin‐induced apoptosis via the inactivation of ERK/p90RSK/HSP27 cascade in SK‐OV‐3 cells as a potent synergist to cisPlatin treatment.

TL;DR: It is suggested that betulinic acid has anti-angiogenic activity by disturbing the binding of HIF-1α and STAT3 to the VEGF promoter in hypoxic PC-3 cells.

TL;DR: Melatonin suppresses HIF‐1α accumulation via inhibition of SPHK1 pathway and ROS generation in PC‐3 cells under hypoxia, and reactive oxygen species (ROS) scavenger N‐acteylcysteine enhanced melatonin‐inhibited HIF-1α expression and SPHK 1 activity.

TL;DR: Findings indicate that anethole is a potent anti-metastatic drug that functions through inhibiting MMP-2/9 and AKT/mitogen-activated protein kinase (MAPK)/NF-κB signal transducers.

TL;DR: It is suggested that Tan IIA induces autophagic cell death via activation of AMPK and ERK and inhibition of mTOR and p70 S6K in KBM‐5 cells as a potent natural compound for leukemia treatment.