S
Seok-Geun Lee
Researcher at Kyung Hee University
Publications - 135
Citations - 6128
Seok-Geun Lee is an academic researcher from Kyung Hee University. The author has contributed to research in topics: Apoptosis & Signal transduction. The author has an hindex of 39, co-authored 132 publications receiving 5277 citations. Previous affiliations of Seok-Geun Lee include Catholic University of Korea & Seoul National University.
Papers
More filters
Journal ArticleDOI
Role of Excitatory Amino Acid Transporter‐2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics
Keetae Kim,Seok-Geun Lee,Timothy P. Kegelman,Zhao-zhong Su,Swadesh K. Das,Rupesh Dash,Santanu Dasgupta,Paola M. Barral,Michael Hedvat,Michael Hedvat,Paul Diaz,John C. Reed,John L. Stebbins,Maurizio Pellecchia,Devanand Sarkar,Paul B. Fisher +15 more
TL;DR: The potential utility of the EAAT2 promoter is emphasized for developing both low and high throughput screening assays to identify novel small molecule regulators of glutamate transport with potential to ameliorate pathological changes occurring during and causing neurodegeneration.
Journal ArticleDOI
Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes
Seok-Geun Lee,Zhao Zhong Su,Zhao Zhong Su,Luni Emdad,Luni Emdad,Pankaj Gupta,Devanand Sarkar,Devanand Sarkar,Alejandra Borjabad,Alejandra Borjabad,David J. Volsky,David J. Volsky,Paul B. Fisher +12 more
TL;DR: The data indicate that ceftriaxone is a potent modulator of glutamate transport in PHFA through NF-κB-mediated EAAT2 promoter activation, and suggest a mechanism for ceftRIaxone modulation of glutamate Transport and for its potential effects on ameliorating specific neurodegenerative diseases through modulation of extracellular glutamate.
Journal ArticleDOI
β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation
Kyung-Ran Park,Dongwoo Nam,Hyung-Mun Yun,Seok-Geun Lee,Hyeung-Jin Jang,Gautam Sethi,Somi Kim Cho,Kwang Seok Ahn +7 more
TL;DR: The findings suggest that CPO can interfere with multiple signaling cascades involved in tumorigenesis and used as a potential therapeutic candidate for both the prevention and treatment of cancer.
Journal ArticleDOI
Molecular Basis of Nuclear Factor-κB Activation by Astrocyte Elevated Gene-1
TL;DR: The present studies elucidate the domains of AEG-1 important for mediating its function and suggest that it might function as a coactivator for NF-kappaB, consequently augmenting expression of genes necessary for invasion of glioma cells.
Journal ArticleDOI
Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling
TL;DR: Overexpression of AEG-1 inhibited serum starvation-induced apoptosis through activation of PI3K-Akt signaling, one of the effector pathways induced by activated Ras, and affected the phosphorylation state of Akt substrates that are implicated in apoptosis suppression.