S
Sook-San Wong
Researcher at St. Jude Children's Research Hospital
Publications - 42
Citations - 1713
Sook-San Wong is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Virus & Influenza A virus subtype H5N1. The author has an hindex of 18, co-authored 31 publications receiving 1426 citations. Previous affiliations of Sook-San Wong include Royal Children's Hospital & Guangzhou Medical University.
Papers
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Journal ArticleDOI
T-705 (Favipiravir) Induces Lethal Mutagenesis in Influenza A H1N1 Viruses in Vitro
Tatiana Baranovich,Sook-San Wong,Jianling Armstrong,Henju Marjuki,Richard J. Webby,Robert G. Webster,Robert G. Webster,Elena A. Govorkova +7 more
TL;DR: The results demonstrate that T-705 induces a high rate of mutation that generates a nonviable viral phenotype and that lethal mutagenesis is a key antiviral mechanism of T-707.
Journal ArticleDOI
Traditional and New Influenza Vaccines
Sook-San Wong,Richard J. Webby +1 more
TL;DR: The process and challenges of the current influenza vaccine platform are discussed as well as new approaches that are being investigated based on the same antigenic target and newer technologies based on different antigenic targets are discussed.
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Infectivity, Transmission, and Pathology of Human-Isolated H7N9 Influenza Virus in Ferrets and Pigs
Hongbo Zhu,Dayan Wang,David J. Kelvin,David J. Kelvin,Lain-Jong Li,Z Zheng,Sun-Woo Yoon,Sook-San Wong,Amber Farooqui,Jin Wang,David Banner,Rirong Chen,R Zheng,Jie Zhou,Yu Zhang,Wenshan Hong,Wei Dong,Q. Cai,M. H. A. Roehrl,M. H. A. Roehrl,Stephen S. H. Huang,Stephen S. H. Huang,Alyson A. Kelvin,T. Yao,Boping Zhou,X. Chen,Gabriel M. Leung,Leo L.M. Poon,Robert G. Webster,Richard J. Webby,Joseph S. M. Peiris,Yi Guan,Yuelong Shu +32 more
TL;DR: A ferret model was used to evaluate the infectivity and transmissibility of A/Shanghai/2/2013 (SH2), a human H7N9 virus isolate, which showed limited capacity for airborne infectivity but efficiently transmitted between ferrets via direct contact, but less efficiently by airborne exposure.
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Mucosal Immune Responses Predict Clinical Outcomes during Influenza Infection Independently of Age and Viral Load
Christine M. Oshansky,Andrew J. Gartland,Sook-San Wong,Trushar Jeevan,David Q.-H. Wang,Philippa L. Roddam,Miguela A. Caniza,Tomer Hertz,John P. DeVincenzo,Richard J. Webby,Paul G. Thomas +10 more
TL;DR: In this paper, an observational cohort study with longitudinal sampling of peripheral and mucosal sites in 84 naturally influenza-infected individuals, including infants, was conducted to test the immunologic basis of severe illness during natural influenza virus infection of children and adults at the site of infection.
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Epigenome targeting by probiotic metabolites
TL;DR: It is hypothesized that the biological function of probiotics may be a result of epigenetic modifications that may explain the wide range of effects observed and lead to more specific and efficacious therapeutic strategies in the prevention or treatment of chronic inflammatory conditions.