S
Sophia Jacob
Researcher at Boston University
Publications - 2
Citations - 890
Sophia Jacob is an academic researcher from Boston University. The author has contributed to research in topics: Haematopoiesis & Somatic cell. The author has an hindex of 1, co-authored 2 publications receiving 550 citations.
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Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice
José J. Fuster,Susan MacLauchlan,María A. Zuriaga,Maya N. Polackal,Allison C. Ostriker,Raja Chakraborty,Chia-Ling Wu,Soichi Sano,Sujatha Muralidharan,Cristina Rius,Jacqueline T Vuong,Sophia Jacob,Varsha Muralidhar,Avril A. B. Robertson,Mark E. Cooper,Vicente Andrés,Karen K. Hirschi,Kathleen A. Martin,Kenneth Walsh +18 more
TL;DR: The effects of the expansion of Tet2-mutant cells in atherosclerosis-prone, low-density lipoprotein receptor–deficient mice are studied and it is found that partial bone marrow reconstitution with TET2-deficient cells was sufficient for their clonal expansion and led to a marked increase in Atherosclerotic plaque size.
Journal Article
Abstract 17099: Mortality From Heart Failure and Dementia in the United States: Centers for Disease Control (CDC) WONDER 1999 to 2015
Jacqueline T Vuong,Sophia Jacob,Kevin M. Alexander,Avinainder Singh,Ronglih Liao,Akshay S. Desai,Sharmila Dorbala +6 more
TL;DR: Dementia complicates the management of heart failure and may be associated with higher risk for death and readmission, and heart failure also share pathophysiologic risk fact...