R
Raja Chakraborty
Researcher at Yale University
Publications - 19
Citations - 1370
Raja Chakraborty is an academic researcher from Yale University. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 10, co-authored 19 publications receiving 823 citations. Previous affiliations of Raja Chakraborty include University of Manitoba & Boston Children's Hospital.
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Journal ArticleDOI
Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice
José J. Fuster,Susan MacLauchlan,María A. Zuriaga,Maya N. Polackal,Allison C. Ostriker,Raja Chakraborty,Chia-Ling Wu,Soichi Sano,Sujatha Muralidharan,Cristina Rius,Jacqueline T Vuong,Sophia Jacob,Varsha Muralidhar,Avril A. B. Robertson,Mark E. Cooper,Vicente Andrés,Karen K. Hirschi,Kathleen A. Martin,Kenneth Walsh +18 more
TL;DR: The effects of the expansion of Tet2-mutant cells in atherosclerosis-prone, low-density lipoprotein receptor–deficient mice are studied and it is found that partial bone marrow reconstitution with TET2-deficient cells was sufficient for their clonal expansion and led to a marked increase in Atherosclerotic plaque size.
Journal ArticleDOI
Promoters to Study Vascular Smooth Muscle.
Raja Chakraborty,Fatima Zahra Saddouk,Ana Catarina Carrao,Diane S. Krause,Daniel Greif,Kathleen A. Martin +5 more
TL;DR: Smooth muscle cells (SMCs) are a critical component of blood vessel walls that provide structural support, regulate vascular tone, and allow for vascular remodeling as discussed by the authors, and smooth muscle cells also exhibit a rema...
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SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2.
Roxana Ola,Sandrine H. Künzel,Feng Zhang,Gael Genet,Raja Chakraborty,Laurence Pibouin-Fragner,Kathleen A. Martin,William C. Sessa,Alexandre Dubrac,Anne Eichmann,Anne Eichmann +10 more
TL;DR: This study reveals SMAD4 as an essential effector of BMP9-10/ALK1 signaling that affects AVM pathogenesis via regulation of CK2 expression and PI3K/AKT1 activation.
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Targeting smooth muscle cell phenotypic switching in vascular disease.
Raja Chakraborty,Payel Chatterjee,Jui M. Dave,Allison C. Ostriker,Daniel Greif,Eva M. Rzucidlo,Kathleen A. Martin +6 more
TL;DR: The mechanisms underlying VSMC phenotypic modulation and how these might be targeted for therapeutic benefit are summarized to lead to novel approaches to treat and prevent cardiovascular disease and restenosis.
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Differential expression of bitter taste receptors in non-cancerous breast epithelial and breast cancer cells.
TL;DR: Interestingly, the expression of T2R4 was downregulated in breast cancer cells, and an increase in intracellular calcium mobilization was observed after the application of bitter agonists, quinine, dextromethorphan, and phenylthiocarbamide that are specific for some of the 5 T2Rs.