S
Sornampillai Sankarapandi
Researcher at Johns Hopkins University
Publications - 10
Citations - 778
Sornampillai Sankarapandi is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Superoxide & Radical. The author has an hindex of 7, co-authored 10 publications receiving 765 citations. Previous affiliations of Sornampillai Sankarapandi include Indian Institute of Technology Madras & Ohio State University.
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Journal ArticleDOI
Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury
Penghai Wang,Hua Chen,Honghua Qin,Sornampillai Sankarapandi,Mark W. Becher,Philip C. Wong,Jay L. Zweier +6 more
TL;DR: It is demonstrated that superoxide is an important mediator of postischemic injury and that increasing intracellular SOD1 dramatically protects the heart from this injury.
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Quantitative Measurement of Superoxide Generation Using the Spin Trap 5-(Diethoxyphosphoryl)-5-methyl- 1-pyrroline-N-oxide☆
TL;DR: DEPMPO is an efficient spin trap which enables specific and sensitive detection and quantitation of superoxide generation and adduct decay and was 40-fold more sensitive than cytochrome c.
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Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway.
TL;DR: Microglial cells generate superoxide via a neutrophil-like NADPH oxidase but exhibit distinctly different time course and magnitude of activation than that seen in neutrophils.
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Bicarbonate is required for the peroxidase function of cu, zn-superoxide dismutase at physiological ph
TL;DR: A comprehensive EPR investigation of the radical production and redox state of the active site copper was performed, and data suggest that HCO3 − bound to Arg141 anchors the neutral H2O2molecule at theactive site copper, enabling its redox cleavage.
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Quantitative Measurement of Superoxide Generation and Oxygen Consumption from Leukocytes Using Electron Paramagnetic Resonance Spectroscopy
TL;DR: EPR spin trapping with DEPMPO together with EPR oximetry methods can be used to provide sensitive and specific quantitation of cellular superoxide generation and oxygen consumption and provide a promising new approach for the measurement of oxygen reduction andsuperoxide generation in cellular systems.