S
Stanley Borowicz
Researcher at University of Illinois at Chicago
Publications - 9
Citations - 570
Stanley Borowicz is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Carcinogenesis & Regulation of gene expression. The author has an hindex of 5, co-authored 9 publications receiving 438 citations. Previous affiliations of Stanley Borowicz include University of Chicago.
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Journal ArticleDOI
The soft agar colony formation assay.
Stanley Borowicz,Michelle Van Scoyk,Sreedevi Avasarala,Manoj Kumar Karuppusamy Rathinam,Jordi Tauler,Rama Kamesh Bikkavilli,Robert A. Winn,Robert A. Winn +7 more
TL;DR: The soft agar colony formation assay shows that expression of Wnt7a ligand and its Frizzled-9 receptor is sufficient to suppress tumor growth in a murine lung carcinoma model.
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Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer.
Rama Kamesh Bikkavilli,Sreedevi Avasarala,M. Van Scoyk,John J. Arcaroli,C Brzezinski,Wei Zhang,Michael G. Edwards,Manoj Kumar Karuppusamy Rathinam,T. Zhou,Jordi Tauler,Stanley Borowicz,Yves A. Lussier,B. A. Parr,Carlyne D. Cool,Robert A. Winn,Robert A. Winn +15 more
TL;DR: It is shown that the loss of Wnt7a is a major contributing factor for increased lung tumorigenesis owing to reduced cellular senescence, and not reduced apoptosis, or autophagy, and thus pro-senescence therapies using either Wnt 7a or its mimic, Iloprost, might represent a new class of therapeutic treatments for lung cancer.
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c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells
TL;DR: The distal BRCA1 promoter region is associated with c-Myc and contributes to BRC a1 gene activation, and breast cancer cells with reduced BRCa1 expression due to depletion of c- myc exhibited impaired DNA repair activity.
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Novel Role for γ-Catenin in the Regulation of Cancer Cell Migration via the Induction of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1).
Marybeth Sechler,Stanley Borowicz,Michelle Van Scoyk,Sreedevi Avasarala,Sereke Zerayesus,Michael G. Edwards,Manoj Kumar Karuppusamy Rathinam,Xiangmin Zhao,Pei Ying Wu,Ke Tang,Rama Kamesh Bikkavilli,Robert A. Winn,Robert A. Winn +12 more
TL;DR: In this article, a role for the affects of γ-catenin on non-small cell lung cancer (NSCLC) cell migration was identified, and the p53-dependent effect was observed.
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In vitro methylation assay to study protein arginine methylation.
Rama Kamesh Bikkavilli,Sreedevi Avasarala,Michelle Van Scoyk,Manoj Kumar Karuppusamy Rathinam,Jordi Tauler,Stanley Borowicz,Robert A. Winn,Robert A. Winn +7 more
TL;DR: A step-by-step protocol to isolate catalytically active PRMT1, a ubiquitously expressed PRMT family member, and can be employed not only for establishing the methylation status of novel physiologicalPRMT1 substrates, but also for understanding the basic mechanism of protein arginine methylation.