S
Stavroula Sofou
Researcher at Johns Hopkins University
Publications - 48
Citations - 1287
Stavroula Sofou is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Liposome & Vesicle. The author has an hindex of 20, co-authored 45 publications receiving 1161 citations. Previous affiliations of Stavroula Sofou include Johns Hopkins University School of Medicine & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Antibody-targeted liposomes in cancer therapy and imaging
Stavroula Sofou,George Sgouros +1 more
TL;DR: The field has advanced in tandem with advances in liposome design and antibody and protein engineering, and Multifunctional liposomes containing ‘layered functionalities’ could potentially be the future direction in targeted lipOSome-based therapy.
Journal Article
Engineered Liposomes for Potential α-Particle Therapy of Metastatic Cancer
Stavroula Sofou,James L. Thomas,Hung-Yin Lin,Michael R. McDevitt,David A. Scheinberg,George Sgouros +5 more
TL;DR: In this article, stable pegylated phosphatidylcholine-cholesterol liposomes with encapsulated 225Ac were developed to retain the potentially toxic daughters at the tumor site.
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Radionuclide carriers for targeting of cancer
TL;DR: The purpose is to give an integrated picture of the general strategies and molecular constructs currently explored for the delivery of therapeutic radionuclides, and to identify challenges that need to be addressed.
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Anti–Prostate-Specific Membrane Antigen Liposomes Loaded with 225Ac for Potential Targeted Antivascular α-Particle Therapy of Cancer
Amey Bandekar,Charles Zhu,Rohit Jindal,Frank Bruchertseifer,Alfred Morgenstern,Stavroula Sofou +5 more
TL;DR: The studies demonstrate that anti-PSMA–targeted liposomes loaded with 225Ac selectively bind, become internalized, and kill PSMA-expressing cells including endothelial cells induced to express PSMA, and suggest the potential of PSma-targeting liposome encapsulating α-particle emitters for selective antivascular α radiotherapy.
Journal ArticleDOI
Enhanced Retention of the α-Particle-Emitting Daughters of Actinium-225 by Liposome Carriers
Stavroula Sofou,Barry J. Kappel,Jaspreet Singh Jaggi,Michael R. McDevitt,David A. Scheinberg,George Sgouros +5 more
TL;DR: In this paper, targeted α-particle emitters hold great promise as therapeutics for micrometastatic disease, because of their high energy deposition and short range, tumor targeted αparticles can result in high c...