Stefan Amisten

TL;DR: It is proposed that GLP-1 inhibits glucagon secretion by PKA-dependent inhibition of the N-type Ca(2+) channels via a small increase in intracellular cAMP ([cAMP](i) and Adrenaline stimulates L- type Ca( 2+) channel-dependent exocytosis by activation of the low-affinity cAMP sensor Epac2 via a large increase in [cAMP]-i.

TL;DR: It is suggested that interferogenic immune complexes stimulate production of IFNα that up-regulates the megakaryocytic type I IFN-regulated genes and proteins and could affect platelet activation and contribute to development of vascular disease in SLE.

TL;DR: This atlas of all GPCRs expressed by human islets is constructed and identifies GPCR/ligand/drug interactions that might affect insulin secretion, which are important for understanding the metabolic side effects of drugs.

TL;DR: Several GPCRs not previously known to be expressed in platelets are detected, including a functional adenosine A(2B) receptor, which could improve the understanding of platelet aggregation and provide new targets for drug development.

TL;DR: In both mouse and human islets, thePalmitate-induced secretion defect was reversed when the β cell action potential was pharmacologically prolonged, and the release competence of the granules was not affected by palmitate.