C
Carsten J. Kirschning
Researcher at University of Duisburg-Essen
Publications - 160
Citations - 26909
Carsten J. Kirschning is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: TLR2 & Immune system. The author has an hindex of 71, co-authored 156 publications receiving 25513 citations. Previous affiliations of Carsten J. Kirschning include University of Duisburg & Technische Universität München.
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Journal ArticleDOI
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
Florian Heil,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Carsten J. Kirschning,Shizuo Akira,Grayson B. Lipford,Hermann Wagner,Stefan Bauer +8 more
TL;DR: It is shown that guanosine (G)- and uridine (U)-rich ssRNA oligonucleotides derived from human immunodeficiency virus–1 (HIV-1) stimulate dendritic cells and macrophages to secrete interferon-α and proinflammatory, as well as regulatory, cytokines, and these data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8.
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Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
Stefan Bauer,Carsten J. Kirschning,Hans Häcker,Vanessa Redecke,Susanne Hausmann,Shizuo Akira,Hermann Wagner,Grayson B. Lipford +7 more
TL;DR: It is shown that human TLR9 expression in human immune cells correlates with responsiveness to bacterial deoxycytidylate-phosphate-deoxyguanylate (CpG)-DNA, and data suggest that hTLR9 conveys CpG-DNA responsiveness to human cells by directly engaging immunostimulating Cpg-DNA.
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HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway
Ramunas M. Vabulas,Parviz Ahmad-Nejad,Sanghamitra Ghose,Carsten J. Kirschning,Rolf D. Issels,Hermann Wagner +5 more
TL;DR: It is found that TLR2 and TLR4 confer responsiveness to HSP70 in 293T fibroblasts and the expanding list of endogenous ligands able to activate the ancient Toll/IL-1 receptor signal pathway is in line with the “danger hypothesis” proposing that the innate immune system senses danger signals even if they originate from self.
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Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells
Ramunas M. Vabulas,Parviz Ahmad-Nejad,Clarissa Prazeres da Costa,Thomas Miethke,Carsten J. Kirschning,Hans Häcker,Hermann Wagner +6 more
TL;DR: To understand the proinflammatory nature of HSP, signaling induced by human and chlamydial HSP60 is analyzed and revealed that adjuvanticity of H SP60 operates similar to that of classical pathogen-derived ligands.
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Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide
TL;DR: In this paper, the role of mammalian Toll-like receptors (TLRs) as signal transducers for LPS was investigated, and it was shown that LPS signaling through TLR2 was dependent on serum which contains soluble CD14 (sCD14).