S
Stefan F. Pinter
Researcher at University of Connecticut
Publications - 23
Citations - 1390
Stefan F. Pinter is an academic researcher from University of Connecticut. The author has contributed to research in topics: XIST & X-inactivation. The author has an hindex of 13, co-authored 21 publications receiving 1239 citations. Previous affiliations of Stefan F. Pinter include Harvard University & University of Connecticut Health Center.
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Journal ArticleDOI
High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation
Matthew D. Simon,Matthew D. Simon,Stefan F. Pinter,Stefan F. Pinter,Rui Fang,Kavitha Sarma,Kavitha Sarma,Michael Rutenberg-Schoenberg,Sarah K. Bowman,Barry Kesner,Barry Kesner,Verena K. Maier,Verena K. Maier,Robert E. Kingston,Jeannie T. Lee,Jeannie T. Lee +15 more
TL;DR: High-resolution maps of Xist binding on the X chromosome across a developmental time course using CHART-seq conclude that Xist spreading takes distinct stage-specific forms, but during maintenance, Xist spreads rapidly to both gene-rich and gene-poor regions.
Journal ArticleDOI
The pluripotency factor, Oct4, interacts with Ctcf and also controls X-chromosome pairing and counting
Mary E. Donohoe,Susana S. Silva,Susana S. Silva,Stefan F. Pinter,Stefan F. Pinter,Na Xu,Na Xu,Jeannie T. Lee +7 more
TL;DR: It is shown that Oct4 (also known as Pou5f1) lies at the top of the XCI hierarchy, and regulates XCI by triggering X-chromosome pairing and counting, the first trans-factor that regulates counting, and ascribed new functions to Oct4 during X- chromosome reprogramming.
Journal ArticleDOI
Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations.
Stefan F. Pinter,Ruslan I. Sadreyev,Ruslan I. Sadreyev,Eda Yildirim,Eda Yildirim,Yesu Jeon,Yesu Jeon,Toshiro K. Ohsumi,Mark L. Borowsky,Jeannie T. Lee,Jeannie T. Lee +10 more
TL;DR: Examining allele-specific binding of Polycomb repressive complex 2 (PRC2) and chromatin composition during XCI and generating a chromosome-wide profile of Xi and Xa (active X) at nucleosome-resolution suggests that XCI is governed by a hierarchy of defined Polycomb stations that spread H3K27 methylation in cis.
Journal ArticleDOI
Locus-specific targeting to the X chromosome revealed by the RNA interactome of CTCF.
Johnny T. Kung,Johnny T. Kung,Barry Kesner,Barry Kesner,Jee Young An,Jee Young An,Janice Y. Ahn,Catherine Cifuentes-Rojas,Catherine Cifuentes-Rojas,David Colognori,David Colognori,Yesu Jeon,Yesu Jeon,Attila Szanto,Attila Szanto,Brian C. Del Rosario,Brian C. Del Rosario,Stefan F. Pinter,Stefan F. Pinter,Jennifer A. Erwin,Jennifer A. Erwin,Jeannie T. Lee +21 more
TL;DR: It is reported that C TCF binds thousands of transcripts in mouse embryonic stem cells, many in close proximity to CTCF's genomic binding sites, and implicates CTCf-RNA interactions in long-range chromosomal interactions.
Journal ArticleDOI
X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription
Eda Yildirim,Ruslan I. Sadreyev,Ruslan I. Sadreyev,Stefan F. Pinter,Stefan F. Pinter,Jeannie T. Lee,Jeannie T. Lee +6 more
TL;DR: This work derives predictive models for relationships among Pol II occupancy, active mark densities and gene expression, and suggests that Xa upregulation involves increased transcription initiation and elongation, without invoking X-specific dependencies between chromatin states and transcription.