R
Ruslan I. Sadreyev
Researcher at Harvard University
Publications - 190
Citations - 10697
Ruslan I. Sadreyev is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 42, co-authored 153 publications receiving 7689 citations. Previous affiliations of Ruslan I. Sadreyev include University of Texas Southwestern Medical Center & Moscow State University.
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Journal ArticleDOI
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
Aaron N. Hata,Matthew J. Niederst,Hannah L. Archibald,Maria Gomez-Caraballo,Faria M. Siddiqui,Hillary E. Mulvey,Yosef E. Maruvka,Yosef E. Maruvka,Fei Ji,Hyo-eun C. Bhang,Viveksagar Krishnamurthy Radhakrishna,Giulia Siravegna,Haichuan Hu,Sana Raoof,Elizabeth L. Lockerman,Anuj Kalsy,Dana Lee,Celina L. Keating,David A. Ruddy,Leah J. Damon,Adam S. Crystal,Carlotta Costa,Zofia Piotrowska,Alberto Bardelli,Anthony J. Iafrate,Ruslan I. Sadreyev,Frank Stegmeier,Gad Getz,Lecia V. Sequist,Anthony C. Faber,Jeffrey A. Engelman +30 more
TL;DR: Findings provide evidence that clinically relevant drug-resistant cancer cells can both pre-exist and evolve from drug-tolerant cells, and they point to therapeutic opportunities to prevent or overcome resistance in the clinic.
Journal ArticleDOI
Macrophages facilitate electrical conduction in the heart
Maarten Hulsmans,Sebastian Clauss,Sebastian Clauss,Ling Xiao,Aaron D. Aguirre,Kevin R. King,Alan Hanley,Alan Hanley,William J. Hucker,Eike M. Wülfers,Gunnar Seemann,Gabriel Courties,Yoshiko Iwamoto,Yuan Sun,Andrej J. Savol,Hendrik B. Sager,Kory J. Lavine,Gregory A. Fishbein,Diane E. Capen,Nicolas Da Silva,Lucile Miquerol,Hiroko Wakimoto,Christine E. Seidman,Christine E. Seidman,Jonathan G. Seidman,Ruslan I. Sadreyev,Kamila Naxerova,Richard N. Mitchell,Dennis Brown,Peter Libby,Ralph Weissleder,Filip K. Swirski,Peter Kohl,Claudio Vinegoni,David J. Milan,David J. Milan,Patrick T. Ellinor,Patrick T. Ellinor,Matthias Nahrendorf +38 more
TL;DR: It is shown that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophage expressing connexin 43.
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The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites
Jason A. West,Christopher P. Davis,Hongjae Sunwoo,Matthew D. Simon,Ruslan I. Sadreyev,Peggy I. Wang,Michael Y. Tolstorukov,Robert E. Kingston +7 more
TL;DR: It is shown that NEAT1 and MALAT1 localize to hundreds of genomic sites in human cells, primarily over active genes and display distinct gene body binding patterns at these sites, suggesting independent but complementary functions for these RNAs.
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Structure prediction for CASP8 with all‐atom refinement using Rosetta
Srivatsan Raman,Robert B. Vernon,James Thompson,Michael D. Tyka,Ruslan I. Sadreyev,Jimin Pei,David E. Kim,Elizabeth H. Kellogg,Frank DiMaio,Oliver F. Lange,Lisa N. Kinch,William Sheffler,Bong Hyun Kim,Rhiju Das,Nick V. Grishin,David Baker +15 more
TL;DR: Improvements over the starting template‐based models and refinement tests demonstrate the power of Rosetta structure refinement in improving model accuracy.
Journal ArticleDOI
Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice
Eda Yildirim,James E. Kirby,Diane E. Brown,Francois Mercier,Ruslan I. Sadreyev,David T. Scadden,Jeannie T. Lee +6 more
TL;DR: It is proposed that Xist loss results in X reactivation and consequent genome-wide changes that lead to cancer, thereby causally linking the X chromosome to cancer in mice.