Stefan Hart

TL;DR: A broad overview of signal transduction networks that are controlled by the EGFR superfamily of receptors in health and disease and its application for target-selective therapeutic intervention is given.

TL;DR: Analysis of GPCR-induced EGFR activation in more than 60 human carcinoma cell lines derived from different tissues has demonstrated the broad relevance of this signalling mechanism in cancer, and support an important role for G PCR ligand-dependent EGFR signal transactivation in diverse pathophysiological disorders.

TL;DR: Evidence is presented that blockade of the TACE by the tissue inhibitor of metalloprotease‐3, a dominant‐negative TACE mutant or RNA interference suppresses GPCR‐stimulated AR release, EGFR activation and downstream events, suggesting TACE can function as an effector of G PCR‐mediated signalling and represents a key element of the cellular receptor cross‐talk network.

TL;DR: It is demonstrated that anandamide, Δ9-tetrahydrocannabinol (THC), HU-210, and Win55,212-2 promote mitogenic kinase signaling in cancer cells and thereby contribute to cancer progression in patients.

TL;DR: FGFR4 contributes significantly to HCC progression by modulating AFP secretion, proliferation and anti-apoptosis and its inhibition a novel and much needed pharmacological approach against HCC.