Stefan Schüchner

TL;DR: It is shown that the yeast Atg5–Atg12/Atg16 complex directly binds membranes, and membrane binding by AtG5 is downstream of its recruitment to the pre‐autophagosomal structure but is essential for autophagy and cytoplasm‐to‐vacuole transport at a stage preceding Atg8 conjugation and vesicle closure.

TL;DR: This work reveals how a small molecule, DT-061, specifically stabilizes the B56α-PP2A holoenzyme in a fully assembled, active state to dephosphorylate selective substrates, such as its well-known oncogenic target, c-Myc.

TL;DR: It is reported that the accumulation of progerin, a truncated form of farnesylated and carboxymethylated prelamin A identified in Hutchinson-Gilford progeria syndrome cells, induces BAF recruitment in the nucleus, suggesting that BAF could mediate prelam in A-induced chromatin remodeling effects.

TL;DR: A protein-proximity assay in yeast based on fusing a histone lysine methyltransferase onto a bait and its substrate onto a prey and detected by methylation-specific antibodies to detect varying interaction affinities among proteins in a mitogen-activated protein kinase pathway.

TL;DR: It is concluded that axonal delivery of SERT is contingent on recruitment of SEC24C in the ER, and that SERT and VMAT2 reach the presynaptic specialization by independent routes.