Julia Romanov

TL;DR: It is shown that the yeast Atg5–Atg12/Atg16 complex directly binds membranes, and membrane binding by AtG5 is downstream of its recruitment to the pre‐autophagosomal structure but is essential for autophagy and cytoplasm‐to‐vacuole transport at a stage preceding Atg8 conjugation and vesicle closure.

TL;DR: This study developed a reconstituted system using purified components and shows that p62 and ubiquitinated proteins spontaneously coalesce into larger clusters, providing mechanistic insights on how substrates are channeled into autophagy.

TL;DR: It is shown that disordered residues 326–380 of p62 directly interact with the C-terminal region of FIP200, providing the molecular basis for a crosstalk between cargo condensation and autophagosome formation.

TL;DR: In this article, the human cargo receptor p62/SQSTM-1 employs oligomerization to stabilize its interaction with LC3B and linear ubiquitin when they are clustered on surfaces.

TL;DR: It is shown that cargo directly activates the cargo receptor Atg19 by exposing multiple Atg8 binding sites in a fully reconstituted system and that cargo receptors contribute to tight membrane bending of the isolation membrane around the cargo.