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Stefania Mai
Researcher at University of Milan
Publications - 12
Citations - 322
Stefania Mai is an academic researcher from University of Milan. The author has contributed to research in topics: Receptor & Gonadotropin-releasing hormone. The author has an hindex of 8, co-authored 9 publications receiving 293 citations.
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Journal ArticleDOI
GnRH Receptors in Cancer: From Cell Biology to Novel Targeted Therapeutic Strategies
Patrizia Limonta,Marina Montagnani Marelli,Stefania Mai,Marcella Motta,Luciano Martini,Roberta M. Moretti +5 more
TL;DR: Tumor GnRH-R are now considered a very interesting candidate for novel molecular, GnRH analog-based, targeted strategies for the treatment of tumors expressing these receptors.
Journal ArticleDOI
Clusterin isoforms differentially affect growth and motility of prostate cells: possible implications in prostate tumorigenesis.
Roberta M. Moretti,Marina Montagnani Marelli,Stefania Mai,Anna Cariboni,Maurizio Scaltriti,Saverio Bettuzzi,Patrizia Limonta +6 more
TL;DR: CLU gene expression might play a crucial role in prostate tumorigenesis by exerting differential biological effects on normal versus tumor cells through differential processing of CLU isoforms in the two cell systems.
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Type I Gonadotropin-Releasing Hormone Receptor Mediates the Antiproliferative Effects of GnRH-II on Prostate Cancer Cells
Marina Montagnani Marelli,Roberta M. Moretti,Stefania Mai,Joanna Januszkiewicz-Caulier,Marcella Motta,Patrizia Limonta +5 more
TL;DR: GnRH-II exerts a specific and significant antiproliferative action on prostate cancer cells and is mediated by the activation of type I (but not of type II) GnRH-R and by its coupled cAMP intracellular signaling pathway.
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Gonadotropin-releasing hormone agonists reduce the migratory and the invasive behavior of androgen-independent prostate cancer cells by interfering with the activity of IGF-I.
Marina Montagnani Marelli,Roberta M. Moretti,Stefania Mai,Patrizia Procacci,Patrizia Limonta +4 more
TL;DR: Data indicate that GnRH agonists, in addition to their well known antiproliferative effect, can also exert a significant inhibitory activity on the migratory and invasive behavior of androgen-independent prostate cancer cells, expressing the GnRH receptor.
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Novel insights into GnRH receptor activity: Role in the control of human glioblastoma cell proliferation
Marina Montagnani Marelli,Roberta M. Moretti,Stefania Mai,Oliver Müller,Johan C. Van Groeninghen,Patrizia Limonta +5 more
TL;DR: The findings suggest that the GnRH receptor might represent a molecular target for an endocrine therapeutical approach against gliomas.