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Stefania Risso Bradley
Researcher at ACADIA Pharmaceuticals Inc.
Publications - 9
Citations - 351
Stefania Risso Bradley is an academic researcher from ACADIA Pharmaceuticals Inc.. The author has contributed to research in topics: Agonist & Muscarinic acetylcholine receptor M1. The author has an hindex of 8, co-authored 9 publications receiving 335 citations. Previous affiliations of Stefania Risso Bradley include Merck & Co..
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Journal ArticleDOI
Structural Requirements of Transmembrane Domain 3 for Activation by the M1 Muscarinic Receptor Agonists AC-42, AC-260584, Clozapine and N-desmethylclozapine: Evidence for three distinct modes of receptor activation
Tracy A. Spalding,Jian-Nong Ma,Thomas R. Ott,Mikael Friberg,Abhishek Bajpai,Stefania Risso Bradley,Robert E. Davis,Mark R. Brann,Ethan S. Burstein +8 more
TL;DR: The results show that M1 receptors can be activated in at least three distinct ways and that there is no requirement for potent muscarinic agonists to mimic acetylcholine interactions with TM3.
Journal ArticleDOI
AC-260584, an orally bioavailable M1 muscarinic receptor allosteric agonist, improves cognitive performance in an animal model
Stefania Risso Bradley,Jelveh Lameh,Linda Ohrmund,Thomas Son,Abhishek Bajpai,Derek Nguyen,Mikael Friberg,Ethan S. Burstein,Tracy A. Spalding,Thomas R. Ott,Hans H. Schiffer,Ali Tabatabaei,Krista McFarland,Robert E. Davis,Douglas W. Bonhaus +14 more
TL;DR: Results indicate for the first time that a M(1) receptor agonist selective over the other mAChR subtypes can have a symptomatically pro-cognitive action.
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The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling
Stefania Risso Bradley,Jason M. Uslaner,Rose B. Flick,Ariel Lee,Kristina M. Groover,Peter H. Hutson +5 more
TL;DR: The findings confirm the hypothesis that mGluR7 could represent a novel target for treating depression and suggest that behaviorally efficacious doses of AMN082 modulate phosphorylation of AMPA and NMDA receptor subunits in the hippocampus.
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Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators.
Nathalie Schlienger,Birgitte W. Lund,Jan Pawlas,Fabrizio Badalassi,Fabio Bertozzi,Rasmus Lewinsky,Alma Fejzic,Mikkel B. Thygesen,Ali Tabatabaei,Stefania Risso Bradley,Luis R. Gardell,Fabrice Piu,Roger Olsson +12 more
TL;DR: The discovery of ACP-105 (1), a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone, is described.
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Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist
Kimberly E. Vanover,Scott C. Harvey,Thomas Son,Stefania Risso Bradley,Henriette Kold,Malath Makhay,Isaac Veinbergs,Tracy Spalding,David M. Weiner,Carl-Magnus A. Andersson,Bo-Ragnar Tolf,Mark R. Brann,Uli Hacksell,Robert E. Davis +13 more
TL;DR: A compound with a similar pharmacological profile as AC-90179 and with increased oral bioavailability may have potential for the treatment of psychosis.