M
Mikkel B. Thygesen
Researcher at University of Copenhagen
Publications - 62
Citations - 2479
Mikkel B. Thygesen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Lotus japonicus & Peptide. The author has an hindex of 23, co-authored 57 publications receiving 1993 citations. Previous affiliations of Mikkel B. Thygesen include ACADIA Pharmaceuticals Inc. & University of Copenhagen Faculty of Science.
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Journal ArticleDOI
Receptor-mediated exopolysaccharide perception controls bacterial infection
Yasuyuki Kawaharada,Simon Kelly,M. Wibroe Nielsen,Christian T. Hjuler,Kira Gysel,Artur Muszyński,Russell W. Carlson,Mikkel B. Thygesen,Niels Sandal,M. H. Asmussen,Maria Vinther,Stig U. Andersen,Lene Krusell,Søren Thirup,Knud J. Jensen,Clive W. Ronson,Mickaël Blaise,Simona Radutoiu,Jens Stougaard +18 more
TL;DR: It is shown that Epr3 expression is inducible and dependent on host perception of bacterial nodulation (Nod) factors, and that plant–bacterial compatibility and bacterial access to legume roots is regulated by a two-stage mechanism involving sequential receptor-mediated recognition of Nod factor and EPS signals.
Journal ArticleDOI
Legume receptors perceive the rhizobial lipochitin oligosaccharide signal molecules by direct binding
Angelique Broghammer,Lene Krusell,Mickaël Blaise,Jørgen Sauer,John T. Sullivan,Nicolai N. Maolanon,Maria Vinther,Andrea Lorentzen,Esben Bjørn Madsen,Knud J. Jensen,Peter Roepstorff,Søren Thirup,Clive W. Ronson,Mikkel B. Thygesen,Jens Stougaard +14 more
TL;DR: The results suggest that ligand recognition through direct ligand binding is a key step in the receptor-mediated activation mechanism leading to root nodule development in legumes.
Journal ArticleDOI
Pharmacological and Behavioral Profile of N-(4-Fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl) Carbamide (2R,3R)-Dihydroxybutanedioate (2:1) (ACP-103), a Novel 5-Hydroxytryptamine2A Receptor Inverse Agonist
Kimberly E. Vanover,David M. Weiner,Malath Makhay,Isaac Veinbergs,Luis R. Gardell,Jelveh Lameh,Andria L. Del Tredici,Fabrice Piu,Hans H. Schiffer,Thomas R. Ott,Ethan S. Burstein,Allan K. Uldam,Mikkel B. Thygesen,Nathalie Schlienger,Carl-Magnus A. Andersson,Thomas Son,Scott C. Harvey,Susan B. Powell,Mark A. Geyer,Bo-Ragner Tolf,Mark R. Brann,Robert E. Davis +21 more
TL;DR: ACP-103 is a potent, efficacious, orally active 5-HT2A receptor inverse agonist with a behavioral pharmacological profile consistent with utility as an antipsychotic agent and demonstrates >42.6% oral bioavailability in rats.
Journal ArticleDOI
Solid-phase chemical tools for glycobiology.
Kim Lambertsen Larsen,Mikkel B. Thygesen,Fanny Guillaumie,William G.T. Willats,Knud J. Jensen +4 more
TL;DR: A comprehensive overview of solid-phase chemical tools for glycobiology including methodologies and applications is provided, including some well-established ones, such as immobilization in microtiter plates and to cross-linked polymers.
Journal ArticleDOI
Impact of chain length on antibacterial activity and hemocompatibility of quaternary N-alkyl and n,n-dialkyl chitosan derivatives.
Priyanka Sahariah,Berglind E. Benediktssdóttir,Martha Á. Hjálmarsdóttir,Olafur E. Sigurjonsson,Kasper K. Sørensen,Mikkel B. Thygesen,Knud J. Jensen,Már Másson +7 more
TL;DR: The most active chitosan derivatives were found to be more selective for killing bacteria than the quaternary ammonium disinfectants cetylpyridinium chloride and benzalkonium chloride, as well as the antimicrobial peptides melittin and LL-37.