S
Stepan Nersisyan
Researcher at National Research University – Higher School of Economics
Publications - 37
Citations - 483
Stepan Nersisyan is an academic researcher from National Research University – Higher School of Economics. The author has contributed to research in topics: Medicine & microRNA. The author has an hindex of 5, co-authored 29 publications receiving 172 citations. Previous affiliations of Stepan Nersisyan include Moscow State University & University of Haifa.
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Journal ArticleDOI
Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19.
Maxim Shkurnikov,Stepan Nersisyan,Tatjana Jankevic,Alexei V. Galatenko,Alexei V. Galatenko,Ivan Gordeev,V. I. Vechorko,Alexander G. Tonevitsky,Alexander G. Tonevitsky +8 more
TL;DR: In this paper, the authors explored whether HLA class I genotypes can be associated with the critical course of Coronavirus Disease-19 by searching possible connections between genotypes of deceased patients and their age at death.
Journal ArticleDOI
Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2.
Stepan Nersisyan,Stepan Nersisyan,Maxim Shkurnikov,Andrey Turchinovich,E N Knyazev,Alexander G. Tonevitsky +5 more
TL;DR: This work searched for putative ACE2 and TMPRSS2 expression regulation networks mediated by various miRNA isoforms (isomiR) across different human organs using publicly available paired miRNA/mRNA-sequencing data from The Cancer Genome Atlas (TCGA) project and identified several miRNA families targeting ACE 2 and TM PRSS2 genes in multiple tissues.
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Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150.
TL;DR: ADAR1 prevents innate immunity activation by cellular transcripts that include extensive duplex RNA structures, and knocking out either protein kinase R (PKR) or mitochondrial antiviral signaling protein (MAVS) in ADAR1KO cells shows that PKR activation elicits a stronger antiviral response.
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Potential role of cellular miRNAs in coronavirus-host interplay
Stepan Nersisyan,Narek Engibaryan,Aleksandra Gorbonos,Ksenia Kirdey,Alexey Makhonin,Alexander G. Tonevitsky +5 more
TL;DR: It is found that miRNA miR-21-3p has the largest probability of binding the human coronavirus RNAs and being dramatically up-regulated in mouse lungs during infection induced by SARS-CoV.
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T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutations.
Stepan Nersisyan,Anton Zhiyanov,Anton Zhiyanov,Maxim Shkurnikov,Alexander G. Tonevitsky,Alexander G. Tonevitsky +5 more
TL;DR: In this paper, the authors developed T-cell COVID-19 Atlas (T-CoV, https://t-cov.hse.ru) -a web portal that allows one to analyze how SARS CoV-2 mutations alter the presentation of viral peptides by HLA molecules.