Stephan Heres

TL;DR: Some sources of bias may limit the validity of head-to-head comparison studies of second-generation antipsychotics, and minor modifications may benefit from minor modifications to help avoid bias.

TL;DR: A systematic review of long-term studies of depot antipsychotic drugs in outpatients with schizophrenia was conducted in this article, where data on relapse, rehospitalization, non-adherence, and dropout due to any reason, inefficacy of treatment and adverse events were summarised in a meta-analysis using a random-effects model.

TL;DR: Among the measures that have the potential to improve adherence to medication are psychosocial interventions, psychoeducation in the form of professional, peer-to-peer or family- to-family interventions, and shared decision making.

TL;DR: Aversions to prescribing depot treatment are frequent among psychiatrists and appear to be unrelated to the antipsychotic class, and further studies are urgently needed to clarify the advantages of depot treatment.

TL;DR: This survey addresses methodological challenges such as the limited generalizability of outcomes due to patient selection and sample size, the vague or even lacking definition of key outcome parameters such as response, remission or relapse, insufficient blinding techniques, the pitfalls of surrogate outcomes and their assessment tools, and the varying complex statistical approaches.