抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

The combination of the compactness of networks, featuring small diameters, and their complex architectures results in a variety of critical effects dramatically different from those in cooperative systems on lattices. In the last few years, important steps have been made toward understanding the qualitatively new critical phenomena in complex networks. The results, concepts, and methods of this rapidly developing field are reviewed. Two closely related classes of these critical phenomena are considered, namely, structural phase transitions in the network architectures and transitions in cooperative models on networks as substrates. Systems where a network and interacting agents on it influence each other are also discussed. A wide range of critical phenomena in equilibrium and growing networks including the birth of the giant connected component, percolation, $k$-core percolation, phenomena near epidemic thresholds, condensation transitions, critical phenomena in spin models placed on networks, synchronization, and self-organized criticality effects in interacting systems on networks are mentioned. Strong finite-size effects in these systems and open problems and perspectives are also discussed.

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Critical phenomena in complex networks

where A represents the magnetic vector potential, is an integral of the hydromagnetic equations. This -integral made it possible to formulate a variational principle for the force-free magnetic fields. The integral expresses the fact that motions cannot transform a given field in an entirely arbitrary different field, if the conductivity of the medium isconsidered infinite. In this paper we shall show that the full set of hydromagnetic equations admit five more integrals, besides the energy integral, if dissipative processes are absent. These integrals, as we shall presently verify, are I2 =fbHvdV, (2)

Proceedings of the National Academy of Sciences

Journal of Statistical Mechanics: theory and experiment

tions. Bootstrap has found many applications in engineering field, including artificial neural networks, biomedical engineering, environmental engineering, image processing, and radar and sonar signal processing. Basic concepts of the bootstrap are summarized in each section as a step-by-step algorithm for ease of implementation. Most of the applications are taken from the signal processing literature. The principles of the bootstrap are introduced in Chapter 2. Both the nonparametric and parametric bootstrap procedures are explained. Babu and Singh (1984) have demonstrated that in general, these two procedures behave similarly for pivotal (Studentized) statistics. The fact that the bootstrap is not the solution for all of the problems has been known to statistics community for a long time; however, this fact is rarely touched on in the manuscripts meant for practitioners. It was first observed by Babu (1984) that the bootstrap does not work in the infinite variance case. Bootstrap Techniques for Signal Processing explains the limitations of bootstrap method with an example. I especially liked the presentation style. The basic results are stated without proofs; however, the application of each result is presented as a simple step-by-step process, easy for nonstatisticians to follow. The bootstrap procedures, such as moving block bootstrap for dependent data, along with applications to autoregressive models and for estimation of power spectral density, are also presented in Chapter 2. Signal detection in the presence of noise is generally formulated as a testing of hypothesis problem. Chapter 3 introduces principles of bootstrap hypothesis testing. The topics are introduced with interesting real life examples. Flow charts, typical in engineering literature, are used to aid explanations of the bootstrap hypothesis testing procedures. The bootstrap leads to second-order correction due to pivoting; this improvement in the results due to pivoting is also explained. In the second part of Chapter 3, signal processing is treated as a regression problem. The performance of the bootstrap for matched filters as well as constant false-alarm rate matched filters is also illustrated. Chapters 2 and 3 focus on estimation problems. Chapter 4 introduces bootstrap methods used in model selection. Due to the inherent structure of the subject matter, this chapter may be difficult for nonstatisticians to follow. Chapter 5 is the most impressive chapter in the book, especially from the standpoint of statisticians. It provides real data bootstrap applications to illustrate the theory covered in the earlier chapters. These include applications to optimal sensor placement for knock detection and land-mine detection. The authors also provide a MATLAB toolbox comprising frequently used routines. Overall, this is a very useful handbook for engineers, especially those working in signal processing.

Probability and Random Processes

Computational complexity is one of the most beautiful fields of modern mathematics, and it is increasingly relevant to other sciences ranging from physics to biology. But this beauty is often buried underneath layers of unnecessary formalism, and exciting recent results like interactive proofs, cryptography, and quantum computing are usually considered too "advanced" to show to the typical student. The aim of this book is to bridge both gaps by explaining the deep ideas of theoretical computer science in a clear and enjoyable fashion, making them accessible to non computer scientists and to computer scientists who finally want to understand what their formalisms are actually telling. This book gives a lucid and playful explanation of the field, starting with P and NP-completeness. The authors explain why the P vs. NP problem is so fundamental, and why it is so hard to resolve. They then lead the reader through the complexity of mazes and games; optimization in theory and practice; randomized algorithms, interactive proofs, and pseudorandomness; Markov chains and phase transitions; and the outer reaches of quantum computing. At every turn, they use a minimum of formalism, providing explanations that are both deep and accessible. The book is intended for graduates and undergraduates, scientists from other areas who have long wanted to understand this subject, and experts who want to fall in love with this field all over again.

The Nature of Computation

A wide variety of methods have been used to compute percolation thresholds. In lattice percolation, the most powerful of these methods consists of microcanonical simulations using the union-find algorithm to efficiently determine the connected clusters, and (in two dimensions) using exact values from conformal field theory for the probability, at the phase transition, that various kinds of wrapping clusters exist on the torus. We apply this approach to percolation in continuum models, finding overlaps between objects with real-valued positions and orientations. In particular, we find precise values of the percolation transition for disks, squares, rotated squares, and rotated sticks in two dimensions and confirm that these transitions behave as conformal field theory predicts. The running time and memory use of our algorithm are essentially linear as a function of the number of objects at criticality.

Continuum percolation thresholds in two dimensions

Using the cavity equations of Mezard, Parisi, and Zecchina [Science 297 (2002), 812]; Mezard and Zecchina, [Phys Rev E 66 (2002), 056126] we derive the various threshold values for the number of clauses per variable of the random K-satisfiability problem, generalizing the previous results to K ≥ 4. We also give an analytic solution of the equations, and some closed expressions for these thresholds, in an expansion around large K. The stability of the solution is also computed. For any K, the satisfiability threshold is found to be in the stable region of the solution, which adds further credit to the conjecture that this computation gives the exact satisfiability threshold.© 2005 Wiley Periodicals, Inc. Random Struct. Alg., 2006

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Threshold values of random K-SAT from the cavity method

Number partitioning is an $\mathrm{NP}$-complete problem of combinatorial optimization. A statistical mechanics analysis reveals the existence of a phase transition that separates the easy- from the hard-to-solve instances and that reflects the pseudopolynomiality of number partitioning. The phase diagram and the value of the typical ground-state energy are calculated.

Phase Transition in the Number Partitioning Problem

Binary sequences with low autocorrelations are important in communication engineering and in statistical mechanics as ground states of the Bernasconi model. Computer searches are the main tool in the construction of such sequences. Owing to the exponential size of the configuration space, exhaustive searches are limited to short sequences. We discuss an exhaustive search algorithm with run-time characteristic and apply it to compile a table of exact ground states of the Bernasconi model up to N = 48. The data suggest F > 9 for the optimal merit factor in the limit .

https://iopscience.iop.org/article/10.1088/0305-4470/29/18/005/pdf

Stephan Mertens

Papers

The Nature of Computation

Continuum percolation thresholds in two dimensions

Threshold values of random K-SAT from the cavity method

Phase Transition in the Number Partitioning Problem

Exhaustive search for low-autocorrelation binary sequences