S
Stephan Pflugmacher
Researcher at University of Helsinki
Publications - 93
Citations - 3488
Stephan Pflugmacher is an academic researcher from University of Helsinki. The author has contributed to research in topics: Ceratophyllum demersum & Aquatic plant. The author has an hindex of 27, co-authored 93 publications receiving 2935 citations. Previous affiliations of Stephan Pflugmacher include Leibniz Association & Kigali Institute of Science and Technology.
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Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication.
Stephan Pflugmacher,Claudia Wiegand,Axel Oberemm,Kenneth A. Beattie,Eberhard Krause,Geoffrey A. Codd,Christian E. W. Steinberg +6 more
TL;DR: The present study shows the existence of a microcystin-LR glutathione conjugate formed enzymatically via soluble glutATHione S-transferase in various aquatic organisms and appears to be the first step in the detoxication of a cyanobacterial toxin in aquatic organisms.
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Uptake and effects of microcystin-LR on detoxication enzymes of early life stages of the zebra fish (Danio rerio)
Claudia Wiegand,Stephan Pflugmacher,Axel Oberemm,Nanke Meems,Kenneth A. Beattie,Christian Steinberg,Geoffrey A. Codd +6 more
TL;DR: There was a detectable uptake of microcystin from the first day of embryonic development up to 5 day old larvae, and because of the differences in volume of the eggs and eleuthero‐embryos, there was an increase in the microcyStin‐LR concentration between these stages.
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Toxicokinetics of atrazine in embryos of the zebrafish (Danio rerio)
TL;DR: Higher atrazine concentrations caused a decrease of GST activity, especially of the sGST of the younger stages, 32 cells and 75% epiboly, which might indicate that the detoxication system itself is affected, which then gives rise to morphological abnormalities during fish development.
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Uptake, effects, and metabolism of cyanobacterial toxins in the emergent reed plant Phragmites australis (Cav.) Trin. ex steud
Stephan Pflugmacher,Claudia Wiegand,Kenneth A. Beattie,Eberhard Krause,Christian E. W. Steinberg,Geoffrey A. Codd +5 more
TL;DR: The commonly occurring cyanobacterial toxin microcystin‐LR was rapidly taken up by the emergent reed plant Phragmites australis with clear distribution in the different cormus parts of the plant, providing the first evidence for the uptake and metabolism of cyanob bacterial toxins by an emergent aquatic macrophyte.
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Exposure to human pharmaceuticals Carbamazepine, Ibuprofen and Bezafibrate causes molecular effects in Dreissena polymorpha
Valeska Contardo-Jara,Claudia Lorenz,Stephan Pflugmacher,Gunnar Nützmann,Werner Kloas,Claudia Wiegand +5 more
TL;DR: Mussels exposed to CBZ and IBU exposed mussels displayed down-regulated mRNA levels of hsp70 and SOD in gills, as well as of MT and P-gp in the digestive gland, hinting on an inhibitory character of CBZ, and a chronic stress condition for the mussels.