S
Stephanie Badaro-Garcia
Researcher at Universidade Estadual de Londrina
Publications - 13
Citations - 225
Stephanie Badaro-Garcia is an academic researcher from Universidade Estadual de Londrina. The author has contributed to research in topics: Inflammation & Medicine. The author has an hindex of 6, co-authored 7 publications receiving 127 citations.
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Journal ArticleDOI
Contribution of Nrf2 Modulation to the Mechanism of Action of Analgesic and Anti-inflammatory Drugs in Pre-clinical and Clinical Stages.
Larissa Staurengo-Ferrari,Stephanie Badaro-Garcia,Miriam S. N. Hohmann,Marília F. Manchope,Tiago H. Zaninelli,Rubia Casagrande,Waldiceu A. Verri +6 more
TL;DR: This review summarizes the molecular mechanisms and pharmacological actions screened that link analgesic, anti-inflammatory, natural products, and other therapies to Nrf2 as a regulatory system based on emerging evidences from experimental disease models and new clinical trial data.
Journal ArticleDOI
15d-PGJ 2 -loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice.
Kenji W. Ruiz-Miyazawa,Larissa Staurengo-Ferrari,Felipe A. Pinho-Ribeiro,Victor Fattori,Tiago H. Zaninelli,Stephanie Badaro-Garcia,Sergio M. Borghi,Ketlem C. Andrade,Juliana Trindade Clemente-Napimoga,José C. Alves-Filho,Thiago M. Cunha,Leonardo Fernandes Fraceto,Fernando Q. Cunha,Marcelo Henrique Napimoga,Rubia Casagrande,Waldiceu A. Verri +15 more
TL;DR: It is demonstrated that 15d-PGJ2-loaded NC present analgesic and anti-inflammatory properties in a PPAR-γ-dependent manner inhibiting IL-1β release and NF-κB activation in GA.
Journal ArticleDOI
Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice.
Larissa Staurengo-Ferrari,Kenji W. Ruiz-Miyazawa,Felipe A. Pinho-Ribeiro,Victor Fattori,Tiago H. Zaninelli,Stephanie Badaro-Garcia,Sergio M. Borghi,Thacyana T. Carvalho,Jose C. Alves-Filho,Thiago M. Cunha,Fernando Q. Cunha,Rubia Casagrande,Waldiceu A. Verri +12 more
TL;DR: The pharmacological effects of trans-Chalcone indicate its therapeutic potential as an analgesic and anti-inflammatory flavonoid for the treatment of gout.
Journal ArticleDOI
Hesperidin methyl chalcone interacts with NFκB Ser276 and inhibits zymosan-induced joint pain and inflammation, and RAW 264.7 macrophage activation
Fernanda S. Rasquel-Oliveira,Marília F. Manchope,Larissa Staurengo-Ferrari,Camila R. Ferraz,Telma Saraiva-Santos,Tiago H. Zaninelli,Victor Fattori,Nayara A. Artero,Stephanie Badaro-Garcia,Andressa de Freitas,Rubia Casagrande,Waldiceu A. Verri +11 more
TL;DR: Data presented in this work suggest the usefulness of HMC as an analgesic and anti-inflammatory in a zymosan-induced arthritis model, possibly by targeting NFκB activation in macrophages.
Journal ArticleDOI
[Ru(bpy)2(NO)SO3](PF6), a Nitric Oxide Donating Ruthenium Complex, Reduces Gout Arthritis in Mice.
Ana C. Rossaneis,Daniela T. Longhi-Balbinot,Mariana M. Bertozzi,Victor Fattori,Carina Z. Segato-Vendrameto,Stephanie Badaro-Garcia,Tiago H. Zaninelli,Larissa Staurengo-Ferrari,Sergio M. Borghi,Thacyana T. Carvalho,Allan J. C. Bussmann,Florêncio S. Gouveia,Luiz Gonzaga de França Lopes,Rubia Casagrande,Waldiceu A. Verri +14 more
TL;DR: The present data is the first evidence that a NO donating ruthenium complex inhibits MSU-induced articular inflammation and pain, and targets the main physiopathological mechanisms of gout arthritis.