Thacyana T. Carvalho

TL;DR: Results demonstrate that 1 exhibits an analgesic effect in a variety of inflammatory pain models by targeting TRPV1 and oxidative stress and by modulating cytokine production.

TL;DR: The present study demonstrated 1 presents analgesic and anti-inflammatory effects in a wide range of murine inflammation models, and its mechanisms of action involves antioxidant effects and NFκB-related inhibition of pro-inflammatory cytokine production.

TL;DR: How the development of formulations containing flavonoids, along with the understanding of their structure-activity relationship, can be harnessed to identify novel flavonoid-based therapies to treat pathological pain and inflammation is focused on.

TL;DR: An important role of oligodendrocyte‐derived IL‐33 in neuropathic pain is revealed, which is dependent on a reciprocal relationship with TNF‐α and IL‐1β and markedly attenuated by inhibitors of PI3K, mammalian target of rapamycin, MAPKs, ERK, and JNK, and also by the inhibitors of glial cells (microglia and astrocytes).

TL;DR: Investigation of intestinal barrier function in KD vasculitis and observed evidence of intestinal permeability and elevated circulating secretory immunoglobulin A in KD patients, as well as elevated sIgA and IgA deposition in vascular tissues in a mouse model of KD Vasculitis demonstrates that IL-1β lies upstream of disrupted intestine barrier function, subsequent IgA vasculopathy development, and cardiac inflammation.