Stephanie J. Fischer

TL;DR: The utility of the nestin-CreERT2/R26R-YFP mouse for inducible gene ablation in stem cells and their progeny in vivo in the two major regions of adult neurogenesis is highlighted.

TL;DR: It is reported here that adult C57BL/6 mice do not have gender differences in hippocampal proliferation or neurogenesis, and the production of new SGZ cells in female mice was not influenced by estrous cycle or after ovariectomy, suggesting that fluctuations in endogenous estradiol levels do not alter adult neuroGenesis in the mouse.

TL;DR: Data suggest that following chronic morphine exposure, factors within the neurogenic microenvironment are maintained or upregulated to compensate for decreased SGZ proliferation.

TL;DR: A functional association between adult neurogenesis and stress induced anxiety- and depressive-like behaviors is suggested, where induced reduction in DCX+ cells at the time of behavioral testing is coupled with stress-induced anxiety and a depressive phenotype, and recovery ofDCX+ cell number corresponds to normalization of these behaviors.

TL;DR: Data show that regulation of mouse SGZ proliferation requires high and relatively stable blood levels of morphine, and provide critical knowledge for the design of future studies to probe the relationship between addiction and neurogenesis.