M
Michael H. Donovan
Researcher at University of Texas Southwestern Medical Center
Publications - 6
Citations - 1259
Michael H. Donovan is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Neurogenesis & Dentate gyrus. The author has an hindex of 5, co-authored 5 publications receiving 1152 citations. Previous affiliations of Michael H. Donovan include University of Texas at Dallas.
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Journal ArticleDOI
Dynamic contribution of nestin-expressing stem cells to adult neurogenesis.
Diane C. Lagace,Mary C. Whitman,Michele A. Noonan,Jessica L. Ables,Nathan A. DeCarolis,Amy A. Arguello,Michael H. Donovan,Stephanie J. Fischer,Laure A. Farnbauch,Robert D. Beech,Ralph J. DiLeone,Charles A. Greer,Chitra D. Mandyam,Amelia J. Eisch +13 more
TL;DR: The utility of the nestin-CreERT2/R26R-YFP mouse for inducible gene ablation in stem cells and their progeny in vivo in the two major regions of adult neurogenesis is highlighted.
Journal ArticleDOI
Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease.
Michael H. Donovan,Umar Yazdani,Rebekah D. Norris,Dora Games,Dwight C. German,Amelia J. Eisch +5 more
TL;DR: An age‐dependent decrease in SGZ proliferation in homozygous PDAPP mice is reported, suggesting altered neurogenesis in the PDAPP mouse may contribute to the age‐related cognitive deficits reported in this model of AD and may be a useful adjunct target for assessing the impact of AD therapies.
Journal ArticleDOI
Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance
Diane C. Lagace,Michael H. Donovan,Nathan A. DeCarolis,Laure A. Farnbauch,Shveta Malhotra,Olivier Berton,Olivier Berton,Eric J. Nestler,Eric J. Nestler,Vaishnav Krishnan,Amelia J. Eisch +10 more
TL;DR: Supporting a functional role for adult-generated dentate gyrus neurons, ablation of neurogenesis via cranial ray irradiation robustly inhibited social avoidance and shows that the time window after cessation of stress is a critical period for the establishment of persistent cellular and behavioral responses to stress.
Journal ArticleDOI
Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus.
TL;DR: Evidence is provided that maturing, but not proliferating, cells in the adult mouse SGZ have the molecular machinery necessary to respond directly to BDNF, and lays critical groundwork for further exploration of the role of BDNF‐TrkB signaling in regulation of adult hippocampal neurogenesis.
Journal ArticleDOI
Stress-Induced Anxiety- and Depressive-Like Phenotype Associated with Transient Reduction in Neurogenesis in Adult Nestin-CreERT2/Diphtheria Toxin Fragment A Transgenic Mice
Sanghee Yun,Michael H. Donovan,Michele N. Ross,Devon R. Richardson,Robin Reister,Laure A. Farnbauch,Stephanie J. Fischer,Dieter Riethmacher,Dieter Riethmacher,Howard K. Gershenfeld,Diane C. Lagace,Amelia J. Eisch +11 more
TL;DR: A functional association between adult neurogenesis and stress induced anxiety- and depressive-like behaviors is suggested, where induced reduction in DCX+ cells at the time of behavioral testing is coupled with stress-induced anxiety and a depressive phenotype, and recovery ofDCX+ cell number corresponds to normalization of these behaviors.