S
Stephen Lambert
Researcher at University of Central Florida
Publications - 50
Citations - 4757
Stephen Lambert is an academic researcher from University of Central Florida. The author has contributed to research in topics: Ankyrin & Schwann cell. The author has an hindex of 28, co-authored 50 publications receiving 4503 citations. Previous affiliations of Stephen Lambert include Howard Hughes Medical Institute & Tufts University.
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Journal ArticleDOI
AnkyrinG Is Required for Clustering of Voltage-gated Na Channels at Axon Initial Segments and for Normal Action Potential Firing
TL;DR: It is demonstrated that ankyrinG is essential for clustering NaCh and neurofascin at axon initial segments and is required for physiological levels of sodium channel activity.
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AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier.
TL;DR: A new ankyrin gene is characterized, expressed in brain and other tissues, that is subject to extensive tissue-specific alternative mRNA processing and has a predicted globular head domain, with membrane- and spectrin-binding activities, as well as an extended "tail" domain.
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Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes
Peter J. Mohler,Ilaria Rivolta,Carlo Napolitano,Guy Lemaillet,Stephen Lambert,Silvia G. Priori,Vann Bennett +6 more
TL;DR: Results in cardiomyocytes suggest that ankyrin-G participates in a common pathway for localization of voltage-gated Na(v) channels at sites of function in multiple excitable cell types.
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Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments.
TL;DR: This is the first characterization of defined neuronal cell adhesion molecules localized to axonal membranes at the node of Ranvier of myelinated axons.
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Induction of sodium channel clustering by oligodendrocytes
Matias Kaplan,Anke Meyer-Franke,Stephen Lambert,Vann Bennett,Ian D. Duncan,Simon R. Levinson,Ben A. Barres +6 more
TL;DR: A crucial role is demonstrated for oligodendrocytes in inducing clustering of sodium channels along axons in vitro and in vivo and the clusters are regularly spaced at the predicted interval in the absence of glial–axonal contact.