Stephen M. Onifer

TL;DR: Results demonstrate, for the first time, a functional change directly linked to anatomical evidence of sprouting by spinal cord afferents after chABC treatment, in the chABC-treated rats.

TL;DR: The anatomical, physiological and behavioral changes that take place in response to injury-induced plasticity after damage to the dorsal column pathway in rats and monkeys are discussed and functional collateral sprouting has been promoted by the post-lesion digestion of the perineuronal net in the cuneate nucleus.

TL;DR: There is a need for standardized small and large animal SCI models as well as quantitative behavioral and electrophysiological assessments of their outcomes so that investigators testing various interventions can directly compare their results and correlate them with the molecular, biochemical, and histological alterations.

TL;DR: This review will describe what is known regarding this phenomenon after traumatic SCI and focus on its relevance to motor and sensory recovery, and discuss a selection of potential approaches for facilitating plasticity as possible SCI treatments.

TL;DR: The data indicate that significant contributions to locomotion from myelinated pathways within the rat DLF can be revealed when combined with simultaneous compromise of the VLF.