James M. Massey

TL;DR: Results demonstrate, for the first time, a functional change directly linked to anatomical evidence of sprouting by spinal cord afferents after chABC treatment, in the chABC-treated rats.

TL;DR: The anatomical, physiological and behavioral changes that take place in response to injury-induced plasticity after damage to the dorsal column pathway in rats and monkeys are discussed and functional collateral sprouting has been promoted by the post-lesion digestion of the perineuronal net in the cuneate nucleus.

TL;DR: Significant increases in the levels of NG2, neurocan and brevican associated with reactive glia throughout the DCN were dramatically increased despite being well beyond areas of trauma-induced blood brain barrier breakdown, demonstrating both an additional challenge and potential treatment strategy for successful functional pathway reconstruction after SCI.

TL;DR: The results are consistent with the proposal that the treatment enhances the sprouting of digit 1 afferents in the cuneate nucleus and that this sprouting allowed these preserved inputs to activate cortex more effectively.

TL;DR: Results indicate that neural transmission between dorsal column primary afferents and cuneate nuclei neurons is likely involved in the recovery of upper limb SSEPs after contusive cervical SCI.