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Stephen P. Malkoski
Researcher at University of Colorado Denver
Publications - 23
Citations - 1094
Stephen P. Malkoski is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 12, co-authored 18 publications receiving 990 citations. Previous affiliations of Stephen P. Malkoski include University of New Mexico & Netherlands Cancer Institute.
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Journal ArticleDOI
Composite Glucocorticoid Regulation at a Functionally Defined Negative Glucocorticoid Response Element of the Human Corticotropin-Releasing Hormone Gene
TL;DR: Results are consistent with a composite mechanism of glucocorticoid-dependent repression involving direct DNA binding of GR and AP-1 nucleoproteins at discrete adjacent sites within the CRH promoter.
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Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation
Sophia Bornstein,Ruth White,Ruth White,Stephen P. Malkoski,Masako Oka,Gangwen Han,Timothy G. Cleaver,Douglas Reh,Peter E. Andersen,Neil D. Gross,Susan B. Olson,Chu-Xia Deng,Shi-Long Lu,Xiao-Jing Wang,Xiao-Jing Wang +14 more
TL;DR: It is found that Smad4 was frequently downregulated not only in human head and neck squamous cell carcinoma (HNSCC) malignant lesions, but also in grossly normal adjacent buccal mucosa and severe inflammation was exhibited, which was associated with increased expression of TGF-beta1 and activated Smad3.
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Novel Stem/Progenitor Cell Population from Murine Tracheal Submucosal Gland Ducts with Multipotent Regenerative Potential
Ahmed E. Hegab,Vi Luan Ha,Jennifer L. Gilbert,Kelvin Xi Zhang,Stephen P. Malkoski,Andy T. Chon,Daphne O. Darmawan,Bharti Bisht,Aik Ooi,Matteo Pellegrini,Derek W. Nickerson,Brigitte N. Gomperts +11 more
TL;DR: It is demonstrated that airway submucosal gland (SMG) duct cells, in addition to BCs, survived severe hypoxic‐ischemic injury and are therefore a multipotent stem cell for airway epithelial repair.
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The Pathology of Bleomycin-Induced Fibrosis Is Associated with Loss of Resident Lung Mesenchymal Stem Cells That Regulate Effector T-cell Proliferation
Du Jun,Chrystelle Garat,James West,Nathalie Thorn,Kelsey Chow,Timothy G. Cleaver,T. Sullivan,Enrique C. Torchia,Christine R. Childs,Theodore R. Shade,Mehrdad Tadjali,Abigail R. Lara,Eva Nozik-Grayck,Stephen P. Malkoski,Brian P. Sorrentino,Barbara Meyrick,Dwight J. Klemm,Mauricio Rojas,David H. Wagner,Susan M. Majka +19 more
TL;DR: It is demonstrated that luMSCs function to protect lung integrity after injury; however, when endogenous MSCs are lost, this function is compromised illustrating the importance of this novel population during lung injury.
Journal ArticleDOI
Localization of a negative glucocorticoid response element of the human corticotropin releasing hormone gene.
TL;DR: It is concluded that (i) cAMP dependent activation of the CRH promoter is mediated primarily by the CRE at -224 bp, (ii) glucocorticoid-dependent repression is specific for theCRH promoter, and not a generalized effect of glucocortsicoid signaling or interference with the protein kinase A (PKA) signaling pathway.