S
Sterghios Moschos
Researcher at Northumbria University
Publications - 49
Citations - 2876
Sterghios Moschos is an academic researcher from Northumbria University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 20, co-authored 43 publications receiving 2533 citations. Previous affiliations of Sterghios Moschos include University of Westminster & University of London.
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Journal ArticleDOI
Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells.
Mark M. Perry,Sterghios Moschos,Andrew E. Williams,Neil J. Shepherd,Hanna M Larner-Svensson,Mark A. Lindsay +5 more
TL;DR: It is demonstrated that changes in the expression of miRNAs can also regulate acute inflammatory responses in human lung alveolar epithelial cells and that rapid increase in miRNA-146a expression provides a novel mechanism for the negative regulation of severe inflammation during the innate immune response.
Journal ArticleDOI
Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.
Sterghios Moschos,Simon W. Jones,Mark M. Perry,Andrew E. Williams,Jonas S. Erjefält,John J. Turner,Peter J. Barnes,Brian Stephen Sproat,Michael John Gait,Mark A. Lindsay +9 more
TL;DR: It is suggested that conjugation to cholesterol may extend but not increase siRNA-mediated p38 MAP kinase mRNA knockdown in the lung, and the use of CPP may be limited due to as yet uncharacterized effects upon gene expression and a potential for immune activation.
Journal ArticleDOI
Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids
Sterghios Moschos,Andrew E. Williams,Mark M. Perry,Mark A. Birrell,Maria G. Belvisi,Mark A. Lindsay +5 more
TL;DR: It is shown that the LPS-induced innate immune response is associated with widespread, rapid and transient increases in miRNA expression in the mouse lung and it is speculated that these changes might be involved in the regulation of the inflammatory response.
Journal ArticleDOI
Role of miRNA-146a in the regulation of the innate immune response and cancer.
Andrew E. Williams,Mark M. Perry,Sterghios Moschos,Hanna M Larner-Svensson,Mark A. Lindsay,Mark A. Lindsay +5 more
TL;DR: The evidence for a role of miR-146a in innate immunity and cancer is reviewed and whether changes in miR -146a might link these two biological responses are assessed.
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Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma.
Eleni Tsitsiou,Andrew E. Williams,Sterghios Moschos,Ketan Patel,Christos Rossios,Xiaoying Jiang,Oona Delpuech Adams,Patricia Macedo,Richard Booton,David Gibeon,Kian Fan Chung,Mark A. Lindsay,Mark A. Lindsay +12 more
TL;DR: Bioinformatics analysis showed that the changes in CD8(+) T-cell mRNA expression were associated with multiple pathways involved in T- cell activation, and severe asthma is associated with the activation of circulating CD8 (+) T cells but not CD4(+) T cells.