D
David Gibeon
Researcher at National Institutes of Health
Publications - 23
Citations - 1686
David Gibeon is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Asthma & Sputum. The author has an hindex of 16, co-authored 23 publications receiving 1348 citations. Previous affiliations of David Gibeon include Imperial College London & National Institute for Health Research.
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Journal ArticleDOI
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
Dominick E. Shaw,Ana R. Sousa,Stephen J. Fowler,Louise Fleming,Graham Roberts,Graham Roberts,Julie Corfield,Julie Corfield,Ioannis Pandis,Aruna T. Bansal,Elisabeth H. Bel,Charles Auffray,Chris Compton,Hans Bisgaard,Enrica Bucchioni,Massimo Caruso,Pascal Chanez,Barbro Dahlén,Sven-Erik Dahlén,Kerry Dyson,Urs Frey,Thomas Geiser,Maria Gerhardsson de Verdier,David Gibeon,Yike Guo,Simone Hashimoto,Gunilla Hedlin,E. Jeyasingham,P.P. Hekking,Tim Higenbottam,Ildiko Horvath,Alan J. Knox,Norbert Krug,Veit J. Erpenbeck,L. Larsson,Nikos Lazarinis,John G. Matthews,Roelinde Middelveld,Paolo Montuschi,Jacek Musiał,David Myles,Laurie Pahus,Thomas Sandström,Wolfgang Seibold,Florian Singer,Karin Strandberg,Jørgen Vestbo,Nadja Hawwa Vissing,Christophe von Garnier,Ian M. Adcock,Scott Wagers,Anthony Rowe,Peter H. Howarth,Ariane H. Wagener,Ratko Djukanovic,Peter J. Sterk,Kian Fan Chung +56 more
TL;DR: U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment, and is well suited to identify asthma phenotypes using the array of "omic" datasets that are at the core of this systems medicine approach.
Journal ArticleDOI
U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics
Diane Lefaudeux,Bertrand De Meulder,Matthew J. Loza,Nancy Peffer,Anthony Rowe,Frédéric Baribaud,Aruna T. Bansal,René Lutter,Ana R. Sousa,Julie Corfield,Ioannis Pandis,Per Bakke,Massimo Caruso,Pascal Chanez,Sven-Erik Dahlén,Louise Fleming,Stephen J. Fowler,Ildiko Horvath,Norbert Krug,Paolo Montuschi,Marek Sanak,Thomas Sandström,Dominic E. Shaw,Florian Singer,Peter J. Sterk,Graham Roberts,Ian M. Adcock,Ratko Djukanovic,Charles Auffray,Kian Fan Chung,Nora Adriaens,H. Ahmed,Antonios Aliprantis,Kjell Alving,Philipp Badorek,David Balgoma,Clair Barber,An Bautmans,Annelie F. Behndig,Elisabeth H. Bel,Jorge Beleta,Ann Berglind,Alix Berton,Jeanette Bigler,Hans Bisgaard,Grazyna Bochenek,Michael Boedigheimer,Klaus Bøonnelykke,Joost Brandsma,Armin Braun,Paul Brinkman,Dominic Burg,Davide Campagna,Leon Carayannopoulos,João P. Carvalho da Purfição Rocha,Amphun Chaiboonchoe,Romanas Chaleckis,Courtney Coleman,Chris Compton,Arnaldo D'Amico,Barbro Dahlén,Jorge De Alba,Pim de Boer,Inge De Lepeleire,Tamara Dekker,Ingrid Delin,Patrick Dennison,Annemiek Dijkhuis,Aleksandra Draper,J. M. Edwards,Rosalia Emma,Magnus Ericsson,Veit J. Erpenbeck,Damijan Erzen,Cornelia Faulenbach,Klaus Fichtner,Neil Fitch,Breda Flood,Urs Frey,Martina Gahlemann,Gabriella Galffy,Hector Gallart,Trevor Garret,Thomas Geiser,Jilaiha Gent,Maria Gerhardsson de Verdier,David Gibeon,Cristina Gómez,Kerry Gove,Neil Gozzard,Yike Guo,Simone Hashimoto,John Haughney,Gunilla Hedlin,Pieter-Paul Hekking,Elisabeth Henriksson,Lorraine Hewitt,Tim Higgenbottam,Uruj Hoda,Jans Hohlfeld,Cecile T.J. Holweg,Peter H. Howarth,Richard Hu,Sile Hu,Xugang Hu,Val Hudson,Anna James,Juliette Kamphuis,Erika Kennington,Dyson Kerry,Matthias Klüglich,Hugo H. Knobel,Richard G. Knowles,Alan J. Knox,Johan Kolmert,Jon R Konradsen,Maxim Kots,Linn Krueger,Scott Kuo,Maciej Kupczyk,Bart N. Lambrecht,Ann-Sofie Lantz,L. Larsson,Nikos Lazarinis,Saeeda Lone-Satif,Lisa Marouzet,Jane Martin,Sarah Masefield,Caroline Mathon,John G. Matthews,Alexander Mazein,Sally Meah,Andrea Maiser,Andrew Menzies-Gow,Leanne Metcalf,Roelinde Middelveld,Maria Mikus,Montse Miralpeix,Philips Monk,Nadia Mores,Clare S. Murray,Jacek Musiał,David Myles,Shama Naz,Katja Nething,Ben Nicholas,Ulf Nihlen,Peter Nilsson,Björn Nordlund,Jörgen Östling,Antonio Pacino,Laurie Pahus,Susanna Palkonnen,Stelios Pavlidis,Giorgio Pennazza,Anne Petrén,Sandy Pink,Anthony D. Postle,Pippa Powel,Malayka Rahman-Amin,Navin Rao,Lara Ravanetti,Emma Ray,Stacey N. Reinke,Leanne Reynolds,Kathrin Riemann,John H. Riley,Martine Robberechts,Amanda Roberts,Christos Rossios,Kirsty E. Russell,Michael Rutgers,Giuseppe Santini,Marco Sentoninco,Corinna Schoelch,James P.R. Schofield,Wolfgang Seibold,Ralf Sigmund,Marcus O.D. Sjödin,Paul Skipp,Barbara Smids,Caroline Smith,J.C. Smith,Katherine M. Smith,Päivi Söderman,Adesimbo Sogbesan,Doroteya Staykova,Karin Strandberg,Kai Sun,David Supple,Marton Szentkereszty,Lilla Tamasi,Kamran Tariq,John-Olof Thörngren,Bob Thornton,Jonathan Thorsen,Salvatore Valente,Wim van Aalderenm,Marianne A. van de Pol,Kees van Drunen,Marleen van Geest,Jenny Versnel,Jørgen Vestbo,Anton Vink,Nadja Hawwa Vissing,Christophe von Garnier,Arianne Wagerner,Scott Wagers,Frans Wald,Samantha Walker,Jonathan Ward,Zsoka Weiszhart,Kristiane Wetzel,Craig E. Wheelock,Coen Wiegman,Siân Williams,Susan J. Wilson,Ashley Woosdcock,Xian Yang,Elizabeth Yeyashingham,Wen Yu,Wilhelm Zetterquist,Koos Zwinderman +222 more
TL;DR: Clustering based on clinicophysiologic parameters yielded 4 stable and reproducible clusters of asthmatic patients that associate with different pathobiological pathways.
Journal ArticleDOI
Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma.
Eleni Tsitsiou,Andrew E. Williams,Sterghios Moschos,Ketan Patel,Christos Rossios,Xiaoying Jiang,Oona Delpuech Adams,Patricia Macedo,Richard Booton,David Gibeon,Kian Fan Chung,Mark A. Lindsay,Mark A. Lindsay +12 more
TL;DR: Bioinformatics analysis showed that the changes in CD8(+) T-cell mRNA expression were associated with multiple pathways involved in T- cell activation, and severe asthma is associated with the activation of circulating CD8 (+) T cells but not CD4(+) T cells.
Journal ArticleDOI
Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma.
TL;DR: ASM from patients with severe asthma shows greater proliferation and IL-6 release than in patients with nonsevere asthma, but both groups show corticosteroid insensitivity.
Journal ArticleDOI
Obesity-Associated Severe Asthma Represents a Distinct Clinical Phenotype: Analysis of the British Thoracic Society Difficult Asthma Registry Patient Cohort According to BMI
David Gibeon,Kannangara Batuwita,Michelle Osmond,Liam G Heaney,Christopher E. Brightling,Robert Niven,Adel H. Mansur,Rekha Chaudhuri,Christine Bucknall,Anthony Rowe,Yike Guo,Pankaj K. Bhavsar,Kian Fan Chung,Andrew Menzies-Gow +13 more
TL;DR: Patients with severe asthma display particular characteristics according to BMI that support the view that obesity-associated severe asthma may represent a distinct clinical phenotype.