S
Stevan D. Stojanović
Researcher at Hannover Medical School
Publications - 10
Citations - 239
Stevan D. Stojanović is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Gene silencing & microRNA. The author has an hindex of 4, co-authored 9 publications receiving 111 citations.
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Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
TL;DR: Senescent cells belonging to various cell types are a dominant and chronic source of a large array of pro-inflammatory cytokines and various additional plaque destabilizing factors, being involved with various aspects of atherosclerosis pathogenesis.
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Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis
Franziska Kenneweg,Claudia Bang,Ke Xiao,Chantal M. Boulanger,Xavier Loyer,Stephane Mazlan,Blanche Schroen,Steffie Hermans-Beijnsberger,Ariana Foinquinos,Marc N. Hirt,Thomas Eschenhagen,Sandra Funcke,Stevan D. Stojanović,Celina Genschel,Katharina Schimmel,Annette Just,Angelika Pfanne,Kristian Scherf,Susann Dehmel,Stella M. Raemon-Buettner,Jan Fiedler,Thomas Thum +21 more
TL;DR: An important novel crosstalk between cardiomyocytes and fibroblasts mediated by the transfer of lncRNA-enriched extracellular vesicles (EVs) in the context of cardiac ischemia is reported.
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Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.
Stevan D. Stojanović,Maximilian Fuchs,Maximilian Fuchs,Meik Kunz,Ke Xiao,Annette Just,Andreas Pich,Johann Bauersachs,Jan Fiedler,Daniel Sedding,Thomas Thum +10 more
TL;DR: Key proteins involved with RNA functionality, HMGB-1 release, LMNB-1 downregulation, in junction with nuclear enlargement, can be used as markers of VSMC senescence, enabling the detection of these pathogenic pro-inflammatory cells in future therapeutic studies in ischemic heart disease and atherosclerosis.
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Combined high-throughput library screening and next generation RNA sequencing uncover microRNAs controlling human cardiac fibroblast biology
Katharina Schimmel,Stevan D. Stojanović,Cheng-Kai Huang,Mira Jung,Martin H. Meyer,Ke Xiao,Lea Grote-Levi,Christian Bär,Angelika Pfanne,Saskia Mitzka,Annette Just,Robert Geffers,Katharina Bock,Franziska Kenneweg,Felix Kleemiß,Christine S. Falk,Jan Fiedler,Thomas Thum +17 more
TL;DR: Evidence is provided that repression of autophagy and detoxification of reactive oxygen species by miR-20a-5p andMiR-132-3p explain some of their pro-fibrotic nature on a mechanistic level.
Journal ArticleDOI
Cardiac endurance training alters plasma profiles of circular RNA MBOAT2.
Anna Meinecke,Saskia Mitzka,Annette Just,Sarah Cushman,Stevan D. Stojanović,Ke Xiao,Frank C. Mooren,Jan Fiedler,Thomas Thum +8 more
TL;DR: The role of circRNA MBOAT2 is confirmed as a promising non-coding RNA biomarker detecting cardiopulmonary adaption after marathon running by demonstrating high stability and conservation of circRNAs as well as its abundance in human plasma.