D
Daniel Sedding
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 127
Citations - 5266
Daniel Sedding is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: Neointima & Vascular smooth muscle. The author has an hindex of 34, co-authored 113 publications receiving 4297 citations. Previous affiliations of Daniel Sedding include Goethe University Frankfurt & University Hospital of Giessen and Marburg.
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Journal ArticleDOI
Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies
TL;DR: Experimental and human evidence strongly suggests the therapeutic potential of antiproliferative therapy for in-stent restenosis, bypass graft failure and other vascular proliferative disorders.
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Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation
Christian Kannemeier,Aya Shibamiya,Fumie Nakazawa,Heidi Trusheim,Clemens Ruppert,Philipp Markart,Yutong Song,Eleni Tzima,Elisabeth Kennerknecht,Michael Niepmann,Marie L von Bruehl,Daniel Sedding,Steffen Massberg,Andreas Günther,Bernd Engelmann,Klaus T. Preissner +15 more
TL;DR: In mice that underwent an arterial thrombosis model, extracellular RNA was found associated with fibrin-rich thrombi, and pretreatment with RNase (but not DNase) significantly delayed occlusive thrombus formation, revealing a yet unrecognized target for antithrombotic intervention, using RNase or related therapeutic strategies.
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Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease.
Christoph Schultheiß,Lisa Paschold,Donjete Simnica,Malte Mohme,Edith Willscher,Lisa von Wenserski,Rebekka Scholz,Imke Wieters,Christine Dahlke,Eva Tolosa,Daniel Sedding,Sandra Ciesek,Marylyn M. Addo,Mascha Binder +13 more
TL;DR: In this paper, the adaptive immunity in COVID-19 patients with active infection or after recovery and created a repository of currently >14 million B and T-cell receptor (BCR and TCR) sequences from the blood of these patients.
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Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension
Rajkumar Savai,Hamza M. Al-Tamari,Daniel Sedding,Baktybek Kojonazarov,Christian Muecke,Rebecca Teske,Mario R. Capecchi,Norbert Weissmann,Friedrich Grimminger,Werner Seeger,Ralph T. Schermuly,Soni Savai Pullamsetti +11 more
TL;DR: It is shown that in pulmonary vessels and PASMCs of human and experimental PH lungs, FoxO1 expression is downregulated and FoxO 1 is inactivated via phosphorylation and nuclear exclusion.
Journal ArticleDOI
Caveolin-1 Facilitates Mechanosensitive Protein Kinase B (Akt) Signaling In Vitro and In Vivo
Daniel Sedding,Jennifer Hermsen,Ulrike Seay,Oliver Eickelberg,Wolfgang Kummer,Carsten Schwencke,Ruth H. Strasser,Harald Tillmanns,Ruediger C. Braun-Dullaeus +8 more
TL;DR: Evidence is provided that PI3-K/Akt is critically involved in mechanotransduction of VSMC in vitro and within the vasculature in vivo and that caveolin-1 is essential for the integrin-mediated activation of PI2-K and Akt.