S
Steve S. Choi
Researcher at Duke University
Publications - 79
Citations - 7510
Steve S. Choi is an academic researcher from Duke University. The author has contributed to research in topics: Hepatic stellate cell & Hedgehog signaling pathway. The author has an hindex of 45, co-authored 79 publications receiving 6696 citations. Previous affiliations of Steve S. Choi include Veterans Health Administration & Durham University.
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Journal ArticleDOI
Mechanisms of disease progression in nonalcoholic fatty liver disease.
TL;DR: As in other types of chronic liver injury, cirrhosis ensues in patients with NAFLD when repair is extreme and sustained, but ultimately unsuccessful, at reconstituting healthy hepatic epithelia.
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Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
Alessia Omenetti,Alessandro Porrello,Youngmi Jung,Liu Yang,Yury Popov,Steve S. Choi,Rafal P. Witek,Gianfranco Alpini,J Venter,Hendrika M.A. VanDongen,Wing-Kin Syn,Gianluca Svegliati Baroni,Antonio Benedetti,Detlef Schuppan,Anna Mae Diehl +14 more
TL;DR: It is found that EMT responses to BDL were enhanced in patched-deficient mice, which display excessive activation of the Hh pathway, and activation of Hh signaling promotes EMT and contributes to the evolution of biliary fibrosis during chronic cholestasis.
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Epithelial‐to‐mesenchymal transitions in the liver
TL;DR: Evidence is summarized that certain resident liver cells are capable of EMTs in vitro and during chronic liver injury, and the theory predicts that the balance between EMT and MET modulates the outcome of Chronic liver injury.
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Hepatic Gene Expression Profiles Differentiate Presymptomatic Patients With Mild Versus Severe Nonalcoholic Fatty Liver Disease
Cynthia A. Moylan,Herbert Pang,Andrew Dellinger,Ayako Suzuki,Melanie E. Garrett,Cynthia D. Guy,Susan K. Murphy,Allison E. Ashley-Koch,Steve S. Choi,Gregory A. Michelotti,Daniel Hampton,Yuping Chen,Hans L. Tillmann,Michael A. Hauser,Manal F. Abdelmalek,Anna Mae Diehl +15 more
TL;DR: By demonstrating specific metabolic and repair pathways that are differentially activated in livers with severe NAFLD, gene profiling identified novel targets that can be exploited to improve diagnosis and treatment of patients who are at greatest risk forNAFLD‐related morbidity and mortality.
Journal ArticleDOI
Hepatic triglyceride synthesis and nonalcoholic fatty liver disease.
Steve S. Choi,Anna Mae Diehl +1 more
TL;DR: Findings suggest that the ability to synthesize triglycerides may, in fact, be protective in obesity, and that liver triglyceride accumulation is actually hepato-protective in obese, insulin-resistant individuals.