G
Gianfranco Alpini
Researcher at Veterans Health Administration
Publications - 434
Citations - 18882
Gianfranco Alpini is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Cholangiocyte & Cholangiocyte proliferation. The author has an hindex of 74, co-authored 384 publications receiving 16288 citations. Previous affiliations of Gianfranco Alpini include University of Rochester & Mayo Clinic.
Papers
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Journal ArticleDOI
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
Alessia Omenetti,Alessandro Porrello,Youngmi Jung,Liu Yang,Yury Popov,Steve S. Choi,Rafal P. Witek,Gianfranco Alpini,J Venter,Hendrika M.A. VanDongen,Wing-Kin Syn,Gianluca Svegliati Baroni,Antonio Benedetti,Detlef Schuppan,Anna Mae Diehl +14 more
TL;DR: It is found that EMT responses to BDL were enhanced in patched-deficient mice, which display excessive activation of the Hh pathway, and activation of Hh signaling promotes EMT and contributes to the evolution of biliary fibrosis during chronic cholestasis.
Journal ArticleDOI
Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules.
TL;DR: These studies indicate that, in the rat, the proliferated bile ductules/ducts spontaneously secrete bile and are the site of secretin choleresis, a property of biliary epithelial cells.
Journal ArticleDOI
Human hepatic stem cell and maturational liver lineage biology.
Rachael Turner,Oswaldo A. Lozoya,Yunfang Wang,Vincenzo Cardinale,Eugenio Gaudio,Gianfranco Alpini,Gemma Mendel,Eliane Wauthier,Claire Barbier,Domenico Alvaro,Lola M. Reid +10 more
TL;DR: Recognition of maturational lineage biology and its regulation by these multiple mechanisms offers new understandings of liver biology, pathologies, and strategies for regenerative medicine and treatment of liver cancers.
Journal ArticleDOI
Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver.
Domenico Alvaro,Maria Grazia Mancino,Shannon Glaser,Eugenio Gaudio,Marco Marzioni,Heather Francis,Gianfranco Alpini +6 more
TL;DR: The purpose of this review is to summarize the recent findings on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangsiocyte biology.
Book
The Pathophysiology of Biliary Epithelia
TL;DR: Significant advances have been made in the understanding of ductal bile formation, including, greater insight into the hormones, intracellular signaling mechanisms, and effector proteins responsible for bile secretion and absorption.