J
J Venter
Researcher at Texas A&M University System
Publications - 14
Citations - 766
J Venter is an academic researcher from Texas A&M University System. The author has contributed to research in topics: Cholestasis & Cholangiocyte. The author has an hindex of 7, co-authored 14 publications receiving 721 citations. Previous affiliations of J Venter include Texas A&M University.
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Journal ArticleDOI
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
Alessia Omenetti,Alessandro Porrello,Youngmi Jung,Liu Yang,Yury Popov,Steve S. Choi,Rafal P. Witek,Gianfranco Alpini,J Venter,Hendrika M.A. VanDongen,Wing-Kin Syn,Gianluca Svegliati Baroni,Antonio Benedetti,Detlef Schuppan,Anna Mae Diehl +14 more
TL;DR: It is found that EMT responses to BDL were enhanced in patched-deficient mice, which display excessive activation of the Hh pathway, and activation of Hh signaling promotes EMT and contributes to the evolution of biliary fibrosis during chronic cholestasis.
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Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin
Marco Marzioni,Shannon Glaser,Heather Francis,Luca Marucci,Antonio Benedetti,Domenico Alvaro,Silvia Taffetani,Yoshiyuki Ueno,Tania Roskams,Jo Lynne Phinizy,J Venter,Giammarco Fava,Gene LeSage,Gianfranco Alpini,Gianfranco Alpini +14 more
TL;DR: The existence of an autocrine loop based on serotonin that limits the growth of the biliary tree in the course of chronic cholestasis is observed and might open new approaches for the management of cholangiopathies.
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Glucagon-Like Peptide-1 and Its Receptor Agonist Exendin-4 Modulate Cholangiocyte Adaptive Response to Cholestasis
Marco Marzioni,Gianfranco Alpini,Gianfranco Alpini,Stefania Saccomanno,Cinzia Candelaresi,J Venter,Chiara Rychlicki,Giammarco Fava,Heather Francis,Luciano Trozzi,Shannon Glaser,Antonio Benedetti +11 more
TL;DR: In this paper, the effects of exposure to GLP-1 and exendin-4 on cholangiocyte growth were investigated. But, the GLP1R signal is mediated by the phosphatidylinositol-3-kinase, cAMP/Protein Kinase A, and Ca2+-CamKIIα but not by the ERK1/2 and PKCα pathways.
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Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts.
Marco Marzioni,Heather Francis,Antonio Benedetti,Yoshiyuki Ueno,Giammarco Fava,Giammarco Fava,J Venter,Ramona Reichenbach,Maria Grazia Mancino,Ryun Summers,Gianfranco Alpini,Shannon Glaser +11 more
TL;DR: UDCA and its taurine conjugate tauroursodeoxycholic acid (TUDCA) were administered in vivo to rats simultaneously subjected to bile duct ligation and vagotomy to improve the response of cholangiopathies to medical therapy.
Journal ArticleDOI
Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis
Marco Marzioni,Gianfranco Alpini,Stefania Saccomanno,Cinzia Candelaresi,J Venter,Chiara Rychlicki,Giammarco Fava,Heather Francis,Luciano Trozzi,Antonio Benedetti +9 more
TL;DR: The hypothesis that exendin-4 may be effective in slowing down the progression of cholangiopathies to ductopenia is supported, due to the ability of exend in-4 to counteract the activation of the mitochondrial pathway of apoptosis.