S
Steve Smith
Publications - 1
Citations - 287
Steve Smith is an academic researcher. The author has contributed to research in topics: Trk receptor & Receptor. The author has an hindex of 1, co-authored 1 publications receiving 206 citations.
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A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.
Alexander Drilon,Alexander Drilon,Ramamoorthy Nagasubramanian,James F. Blake,Nora Ku,Brian B. Tuch,Kevin Ebata,Steve Smith,Veronique Lauriault,Kolakowski Gabrielle R,Barbara J. Brandhuber,Paul D. Larsen,Karyn Bouhana,Shannon L. Winski,R. Hamor,Wen-I Wu,Andrew Parker,Tony Morales,Francis X. Sullivan,Walter E. DeWolf,Lance Wollenberg,Paul Gordon,Dorothea N. Douglas-Lindsay,Maurizio Scaltriti,Ryma Benayed,Sandeep Raj,Bethany Hanusch,Alison M. Schram,Philip Jonsson,Michael F. Berger,Michael F. Berger,Jaclyn F. Hechtman,Jaclyn F. Hechtman,Barry S. Taylor,Steve Andrews,S. Michael Rothenberg,David M. Hyman,David M. Hyman +37 more
TL;DR: LOXO-195 abrogated resistance in TRK fusion-positive cancers that acquired kinase domain mutations, a shared liability with all existing TRK TKIs, establishes a role for sequential treatment by demonstrating continued TRK dependence and validates a paradigm for the accelerated development of next-generation inhibitors against validated oncogenic targets.