S
Steve Szabo
Researcher at Johns Hopkins University
Publications - 10
Citations - 7057
Steve Szabo is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Mutation & Carcinogenesis. The author has an hindex of 8, co-authored 10 publications receiving 6654 citations. Previous affiliations of Steve Szabo include Howard Hughes Medical Institute.
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Journal ArticleDOI
High frequency of mutations of the PIK3CA gene in human cancers
Yardena Samuels,Zhenghe Wang,Alberto Bardelli,Natalie Silliman,Janine Ptak,Steve Szabo,Hai Yan,Adi F. Gazdar,Steven M. Powell,Gregory J. Riggins,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +14 more
TL;DR: To determine if PI3Ks are genetically altered in tumorigenesis, they were sequenced in human for the first time and the results allowed us to assess the importance of phosphatidylinositol 3-kinases in neoplasia.
Journal ArticleDOI
Detection and quantification of mutations in the plasma of patients with colorectal tumors.
Frank Diehl,Meng Li,Devin Dressman,Yiping He,Dong Shen,Steve Szabo,Luis A. Diaz,Steven N. Goodman,Kerstin David,Hartmut Juhl,Kenneth W. Kinzler,Bert Vogelstein +11 more
TL;DR: Patients with advanced colorectal cancers consistently contained mutant adenomatous polyposis coli (APC) DNA molecules in their plasma, which has implications for the mechanisms through which tumor DNA is released into the circulation and for diagnostic tests based on this phenomenon.
Journal ArticleDOI
The PIK3CA gene is mutated with high frequency in human breast cancers
Kurtis E. Bachman,Pedram Argani,Yardena Samuels,Natalie Silliman,Janine Ptak,Steve Szabo,Hiroyuki Konishi,Bedri Karakas,Brian G. Blair,Clarence Lin,Brock A. Peters,Victor E. Velculescu,Ben Ho Park +12 more
TL;DR: It is shown that thirteen of fifty-three breast cancers contain somatic mutations in PIK3CA, with the majority of mutations located in the kinase domain, demonstrating that Pik3CA is the most mutated oncogene in breast cancer.
Journal ArticleDOI
Colorectal cancer: mutations in a signalling pathway.
D. Williams Parsons,Tian Li Wang,Yardena Samuels,Alberto Bardelli,Alberto Bardelli,Jordan M. Cummins,Laura DeLong,Natalie Silliman,Janine Ptak,Steve Szabo,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Christoph Lengauer,Victor E. Velculescu +15 more
TL;DR: Analysis of human colorectal cancers for genetic mutations in 340 serine/threonine kinases found mutations in eight genes, including three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway, which may provide new targets for therapeutic intervention.
Journal ArticleDOI
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Zhenghe Wang,Dong Shen,D. Williams Parsons,Alberto Bardelli,Jason Sager,Steve Szabo,Janine Ptak,Natalie Silliman,Brock A. Peters,Michiel S. van der Heijden,Giovanni Parmigiani,Hai Yan,Tian Li Wang,Greg Riggins,Steven M. Powell,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +19 more
TL;DR: Observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention.